2023
Transendothelial Migration of Human B Cells: Chemokine versus Antigen.
Wang V, Pober J, Manes T. Transendothelial Migration of Human B Cells: Chemokine versus Antigen. The Journal Of Immunology 2023, 211: 923-931. PMID: 37530585, PMCID: PMC10529164, DOI: 10.4049/jimmunol.2200887.Peer-Reviewed Original ResearchConceptsB cellsLeukocyte cell adhesion moleculeTransendothelial migrationEndothelial cellsCell adhesion moleculeAdhesion moleculesPeripheral blood CD19B cell subsetsMemory B cellsInnate immune propertiesSites of inflammationMicrovascular endothelial cellsHuman microvascular endothelial cellsHuman B cellsBlood CD19Peripheral bloodCell subsetsVenular flowT cellsICAM-1VCAM-1Immune propertiesSyk activationChemokinesExpression of genes
1993
Four different classes of inhibitors of receptor-mediated endocytosis decrease tumor necrosis factor-induced gene expression in human endothelial cells.
Bradley JR, Johnson DR, Pober JS. Four different classes of inhibitors of receptor-mediated endocytosis decrease tumor necrosis factor-induced gene expression in human endothelial cells. The Journal Of Immunology 1993, 150: 5544-55. PMID: 8390537, DOI: 10.4049/jimmunol.150.12.5544.Peer-Reviewed Original ResearchConceptsIFN-gamma-mediated inductionELAM-1Human endothelial cellsEndothelial cellsMHC moleculesReceptor-mediated endocytosisCytokine-inducible moleculesAnti-inflammatory therapyIL-1-induced increaseClass II MHC moleculesICAM-1 expressionClass I MHC moleculesVCAM-1 expressionCultured human endothelial cellsII MHC moleculesI MHC moleculesNew potential targetsICAM-1VCAM-1Levels of mRNADensity lipoproteinExposure of cellsTNFGene expressionTNF induction
1992
Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. Correlation with CD3+ T cell infiltration.
Briscoe DM, Cotran RS, Pober JS. Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. Correlation with CD3+ T cell infiltration. The Journal Of Immunology 1992, 149: 2954-60. PMID: 1383333, DOI: 10.4049/jimmunol.149.9.2954.Peer-Reviewed Original ResearchConceptsT cell infiltrationEndothelial VCAM-1 expressionVCAM-1 expressionIL-4Cell infiltrationEndothelial leukocyte adhesion moleculeVCAM-1T cellsAbility of TNFT-cell-rich infiltrateImmunocytochemical stainingVascular cell adhesion molecule-1Endothelial cell adhesion molecule expressionAdhesion moleculesCell adhesion molecule-1Adhesion molecules ELAM-1Cell adhesion molecule expressionInjection of LPST cell extravasationAdhesion molecule expressionEndothelial VCAM-1Tumor necrosis factorAdhesion molecule-1Endothelial adhesion moleculesLeukocyte adhesion molecules
1990
The Endothelial Cell as a Regulator of T‐Cell Function
Hughes. C, Savage C, Pober JS. The Endothelial Cell as a Regulator of T‐Cell Function. Immunological Reviews 1990, 117: 85-102. PMID: 2258192, DOI: 10.1111/j.1600-065x.1990.tb00568.x.Peer-Reviewed Original ResearchConceptsIL-2 productionT cell IL-2 productionT cellsClass II moleculesLFA-3Peripheral blood mononuclear cellsAntigen-presenting capacityMemory T cellsMHC class II moleculesBlood mononuclear cellsNon-immune cell typesT cell functionNon-polymorphic regionsT cell linesCostimulatory cellsMononuclear cellsIL-2Allospecific CTLICAM-1IFN-gammaVCAM-1Immunosuppressive drug CsAAbility of ECCostimulator activityVLA-4