Costimulators expressed on human endothelial cells modulate antigen-dependent recruitment of circulating T lymphocytes
Manes TD, Wang V, Pober JS. Costimulators expressed on human endothelial cells modulate antigen-dependent recruitment of circulating T lymphocytes. Frontiers In Immunology 2022, 13: 1016361. PMID: 36275645, PMCID: PMC9582530, DOI: 10.3389/fimmu.2022.1016361.Peer-Reviewed Original ResearchConceptsT effector cellsT cellsTransendothelial migrationEndothelial cellsCheckpoint inhibitorsEffector cellsCytokine productionCytokine synthesisPeripheral blood T cell subpopulationsEffector memory T cellsEngagement of OX40Presentation of superantigensRegulatory T cellsMemory T cellsT cell subpopulationsT-cell typeT cell CD28Antigen-independent signalT cell activationT cell receptorHuman dermal microvascularCD8 effectorsT-regsHuman endothelial cellsActivated CD4