Ex vivo isolated human vessel perfusion system for the design and assessment of nanomedicines targeted to the endothelium
Lysyy T, Bracaglia LG, Qin L, Albert C, Pober JS, Tellides G, Saltzman WM, Tietjen GT. Ex vivo isolated human vessel perfusion system for the design and assessment of nanomedicines targeted to the endothelium. Bioengineering & Translational Medicine 2020, 5: e10154. PMID: 32440561, PMCID: PMC7237142, DOI: 10.1002/btm2.10154.Peer-Reviewed Original ResearchVessel perfusion systemAnimal modelsPerfusion systemProcess of inflammationVessel segmentsSame human donorEffective clinical translationImmunodeficient miceUmbilical cordRodent modelsHuman donorsEndothelial cellsHuman vesselsBiologic relevanceBiologic replicatesClinical translationSubsequent studiesEfficacyCultured cellsModular chambersCell culturesVivoCellsQuantitative assayVessels