2020
Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys
DiRito JR, Hosgood SA, Reschke M, Albert C, Bracaglia LG, Ferdinand JR, Stewart BJ, Edwards CM, Vaish AG, Thiru S, Mulligan DC, Haakinson DJ, Clatworthy MR, Saltzman WM, Pober JS, Nicholson ML, Tietjen GT. Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys. American Journal Of Transplantation 2020, 21: 161-173. PMID: 32627324, PMCID: PMC7775334, DOI: 10.1111/ajt.16148.Peer-Reviewed Original ResearchConceptsNormothermic machine perfusionHuman kidneyMicrovascular obstructionMarginal organsHigh-risk donorsSevere organ shortageLikelihood of complicationsMicrovascular blood flowAccumulation of fibrinogenCold storage injuryTissue plasminogen activatorImmediate translational potentialMicrovascular pluggingRenal functionRenal injuryMachine perfusionTubular epitheliumBlood flowIntravascular releaseOrgan shortagePhysiologic impactKidneyTranslational potentialPlasminogen activatorVivo assessment
1989
Effects of cytokines on vascular endothelium: Their role in vascular and immune injury
Cotran R, Pober J. Effects of cytokines on vascular endothelium: Their role in vascular and immune injury. Kidney International 1989, 35: 969-975. PMID: 2651773, DOI: 10.1038/ki.1989.80.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEffects of cytokinesEndothelial cellsCytokine-induced effectsRenal injuryEndothelial functionImmune injuryEndothelial activationVascular toneRenal endotheliumImmune functionCell injuryVascular endotheliumCritical homeostatic functionsEndothelium participatesClinical settingHomeostatic functionsTranscapillary permeabilityCytokinesInjurySpecific alterationsInflammationControl of proliferationHematopoietic cellsEndotheliumRecent studies