2016
Complement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice
Qin L, Li G, Kirkiles‐Smith N, Clark P, Fang C, Wang Y, Yu Z, Devore D, Tellides G, Pober J, Jane‐Wit D. Complement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice. American Journal Of Transplantation 2016, 16: 2865-2876. PMID: 27104811, PMCID: PMC5075274, DOI: 10.1111/ajt.13834.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryAllograft vasculopathyEndothelial cell activationReperfusion injuryCell activationComplement C5 inhibitionNuclear factor kappa BSolid organ transplantsT cell infiltrationTerminal complement activationVCAM-1 expressionComplement C5 activationFactor kappa BNeutrophil infiltrationHumanized miceDiffuse stenosisIntraluminal thrombosisArterial graftsC5 inhibitionCell infiltrationHumanized modelNeointimal hyperplasiaOrgan transplantsAlloantibodiesNF-kB
1993
Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I.
Bradley JR, Johnson DR, Pober JS. Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I. American Journal Of Pathology 1993, 142: 1598-609. PMID: 8098585, PMCID: PMC1886909.Peer-Reviewed Original ResearchConceptsIntercellular adhesion molecule-1Tumor necrosis factorAdhesion molecule-1Major histocompatibility complex class I.Major histocompatibility complex class IHistocompatibility complex class IMolecule-1Complex class IInterleukin-1Intercellular adhesion molecule-1 surface expressionMumol/L hydrogen peroxideVascular cell adhesion molecule-1Transcription factor nuclear factor kappa BEndothelial leukocyte adhesion molecule-1Class ICell adhesion molecule-1Leukocyte-derived cytokinesNuclear factor kappa BVascular endothelial cell functionLeukocyte adhesion molecule-1Surface expressionClass I.Factor kappa BEC surface receptorsEndothelial cell function