Tumor Necrosis Factor Alpha Increases Human Cerebral Endothelial Cell Gb3 and Sensitivity to Shiga Toxin
Eisenhauer P, Chaturvedi P, Fine R, Ritchie A, Pober J, Cleary T, Newburg D. Tumor Necrosis Factor Alpha Increases Human Cerebral Endothelial Cell Gb3 and Sensitivity to Shiga Toxin. Infection And Immunity 2001, 69: 1889-1894. PMID: 11179369, PMCID: PMC98098, DOI: 10.1128/iai.69.3.1889-1894.2001.Peer-Reviewed Original ResearchConceptsHemolytic uremic syndromeShiga toxinMicrovascular brain endothelial cellsCentral nervous system pathologyTumor necrosis factor alphaEndothelial cellsShiga toxin toxicityNervous system pathologyBrain endothelial cellsNecrosis factor alphaTNF-alpha treatmentUmbilical vein endothelial cellsCNS involvementVein endothelial cellsUremic syndromeIntestinal infectionsShiga Toxin BindingFactor alphaEnterohemorrhagic Escherichia coliSystem pathologyFunctional receptorsNormal fatty acidsToxin bindingFatty acidsToxin