Molecular Studies of von Willebrand Disease: Reduced von Willebrand Factor Biosynthesis, Storage, and Release in Endothelial Cells Derived From Patients With Type I von Willebrand Disease
Ewenstein B, Inbal A, Pober J, Handin R. Molecular Studies of von Willebrand Disease: Reduced von Willebrand Factor Biosynthesis, Storage, and Release in Endothelial Cells Derived From Patients With Type I von Willebrand Disease. Blood 1990, 75: 1466-1472. DOI: 10.1182/blood.v75.7.1466.1466.Peer-Reviewed Original ResearchMessenger RNALess messenger RNAVon Willebrand factorEndothelial cellsCultured umbilical vein endothelial cellsRegulated secretionForms of vWDUmbilical vein endothelial cellsStorage organellesFactor biosynthesisVein endothelial cellsMRNA transcriptionVWF proteinMolecular defectsMolecular studiesVWF alleleVon Willebrand diseaseSubsequent translationProteinStorage poolCellsWillebrand diseaseType I von Willebrand diseaseWillebrand factorTranscription