1990
Molecular Studies of von Willebrand Disease: Reduced von Willebrand Factor Biosynthesis, Storage, and Release in Endothelial Cells Derived From Patients With Type I von Willebrand Disease
Ewenstein B, Inbal A, Pober J, Handin R. Molecular Studies of von Willebrand Disease: Reduced von Willebrand Factor Biosynthesis, Storage, and Release in Endothelial Cells Derived From Patients With Type I von Willebrand Disease. Blood 1990, 75: 1466-1472. DOI: 10.1182/blood.v75.7.1466.1466.Peer-Reviewed Original ResearchMessenger RNALess messenger RNAVon Willebrand factorEndothelial cellsCultured umbilical vein endothelial cellsRegulated secretionForms of vWDUmbilical vein endothelial cellsStorage organellesFactor biosynthesisVein endothelial cellsMRNA transcriptionVWF proteinMolecular defectsMolecular studiesVWF alleleVon Willebrand diseaseSubsequent translationProteinStorage poolCellsWillebrand diseaseType I von Willebrand diseaseWillebrand factorTranscription
1985
Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis
Collins T, Ginsburg D, Boss J, Orkin S, Pober J. Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis. Nature 1985, 316: 748-750. PMID: 4033772, DOI: 10.1038/316748a0.Peer-Reviewed Original ResearchConceptsHuman endothelial cellsSequence analysisB chainComplementary DNA clonePDGF B-chainApparent relative molecular massEndothelial cellsChains of PDGFRelative molecular massNorthern blot analysisComplete sequence analysisNormal human endothelial cellsPlatelet-derived growth factorPlatelet-derived growth factor B-chainGrowth factor B-chainDNA clonesPrecursor polypeptideCDNA cloningStriking homologyVascular smooth muscle cellsProtein productsMolecular massPolypeptide chainMessenger RNACultured human endothelial cells