2007
Tumor Necrosis Factor
Pober J. Tumor Necrosis Factor. 2007, 261-265. DOI: 10.1017/cbo9780511546198.032.Peer-Reviewed Original ResearchHemorrhagic necrosisNecrosis factorMediator of cachexiaMediators of inflammationTumor necrosis factorPrimary cellular sourceAdaptive immune systemTNF-like moleculeTime of cloningMajor histocompatibility complexPeyer's patchesEndogenous mediatorsT lymphocytesMast cellsParasitic infectionsTNFBacterial productsExperimental tumorsImmune systemMononuclear phagocytesCellular sourceSmall intestineHistocompatibility complexTNF geneRelated receptors
1991
Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells.
Salomon RN, Hughes CC, Schoen FJ, Payne DD, Pober JS, Libby P. Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells. American Journal Of Pathology 1991, 138: 791-8. PMID: 2012171, PMCID: PMC1886118.Peer-Reviewed Original ResearchConceptsHuman cardiac allograftsCoronary arteryT lymphocytesCardiac allograftsEndothelial cellsT cellsChronic immune reactionsDonor coronary arteriesRecipient T lymphocytesRegional immune responsesClass II major histocompatibility complexGraft endothelial cellsSmooth muscle cell proliferationAllogeneic T cellsAbility of HLAHuman arteriesLong-term survivalMuscle cell proliferationCoronary arterial endotheliumMajor histocompatibility complexNormal human arteriesTypical atherosclerosisOcclusive diseaseHLA-DRTransplanted hearts
1986
Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.
Collins T, Lapierre LA, Fiers W, Strominger JL, Pober JS. Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 446-450. PMID: 3455781, PMCID: PMC322876, DOI: 10.1073/pnas.83.2.446.Peer-Reviewed Original ResearchConceptsClass II MHC antigensTumor necrosis factorClass I major histocompatibility complexI major histocompatibility complexRecombinant human tumor necrosis factorMajor histocompatibility complexHuman tumor necrosis factorHuman endothelial cellsMHC antigensSurface expressionNecrosis factorMRNA levelsHuman dermal fibroblastsEndothelial cellsClass IPresence of TNFCultured human endothelial cellsType I interferonVascular endothelial cellsMHC gene expressionMHC gene regulationDermal fibroblastsImmunoregulatory moleculesB antigensI interferonPhysiologic Regulation of Class II Major Histocompatibility Complex Gene Expression
Collins T, Pober J, Strominger J. Physiologic Regulation of Class II Major Histocompatibility Complex Gene Expression. 1986, 14-31. DOI: 10.1007/978-3-642-70367-6_2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsClass II determinantsNominal antigenMajor histocompatibility complexSpecific effector cellsClass II major histocompatibility complexT helper cellsAntigen-presenting cellsClass II antigensCase of transplantationMajor histocompatibility complex gene expressionT-inducer cellsClass II major histocompatibility complex gene expressionT cell antigen receptorAccessory capacityEffector cellsAllogeneic responseHelper cellsInducer cellsII antigensImmune responsivenessImmune systemCell antigen receptorAntigenAntigen receptorHistocompatibility complex
1984
Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens
Pober JS, Gimbrone MA, Collins T, Cotran RS, Ault KA, Fiers W, Krensky AM, Clayberger C, Reiss C, Burakoff SJ. Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens. Immunobiology 1984, 168: 483-494. PMID: 6397428, DOI: 10.1016/s0171-2985(84)80132-1.Peer-Reviewed Original ResearchConceptsClass II antigensVascular endothelial cellsMajor histocompatibility complexII antigensT cellsClass II moleculesHuman vascular endothelial cellsActivated T cellsEndothelial cellsStromal cellsImmune interferonT lymphocytesAntigen-specific T cellsPeripheral blood T lymphocytesClass IHelper T cell clonesImmune accessory functionNon-MHC antigensWithdrawal of interferonClass II major histocompatibility complexCultured human vascular endothelial cellsT cell responsesVascular smooth muscle cellsBlood T lymphocytesHuman class II antigens
1981
Transglutaminase modifies the carboxy-terminal intracellular region of HLA-A and -B antigens
Pober J, Strominger J. Transglutaminase modifies the carboxy-terminal intracellular region of HLA-A and -B antigens. Nature 1981, 289: 819-821. PMID: 6110191, DOI: 10.1038/289819a0.Peer-Reviewed Original Research