1994
Porcine aortic endothelial cells activate human T cells: Direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28
Murray A, Khodedoust M, Pober J, Bothwell A. Porcine aortic endothelial cells activate human T cells: Direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1994, 1: 57-63. PMID: 7889399, DOI: 10.1016/1074-7613(94)90009-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigens, HeterophileCD2 AntigensCD28 AntigensCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedEndothelium, VascularHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansIn Vitro TechniquesLigandsLymphocyte ActivationSpecies SpecificitySwineT-LymphocytesConceptsPorcine aortic endothelial cellsHuman umbilical vein endothelial cellsHuman T cellsCTLA-4-IgT cellsAortic endothelial cellsEndothelial cellsCultured porcine aortic endothelial cellsMHC class II moleculesClass II moleculesMHC class IUmbilical vein endothelial cellsVein endothelial cellsAllogeneic responseMHC antigensHuman CD8CD28 pathwayCD8 moleculesHuman CD4Species-specific monoclonal antibodiesCD2 pathwayMonoclonal antibodiesClass IDirect presentationCD4
1988
Three distinct classes of regulatory cytokines control endothelial cell MHC antigen expression. Interactions with immune gamma interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte alpha and fibroblast beta interferons.
Lapierre LA, Fiers W, Pober JS. Three distinct classes of regulatory cytokines control endothelial cell MHC antigen expression. Interactions with immune gamma interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte alpha and fibroblast beta interferons. Journal Of Experimental Medicine 1988, 167: 794-804. PMID: 2450953, PMCID: PMC2188900, DOI: 10.1084/jem.167.3.794.Peer-Reviewed Original ResearchConceptsIFN-alphaIL-6Endothelial cellsClass IAction of lymphotoxinMHC antigen expressionIFN-alpha/betaClass II antigensClass I expressionClass II inductionTumor necrosis factorCultured human endothelial cellsClass I MHCRecombinant preparationsHuman endothelial cellsCytokine administrationMHC antigensII antigensPatient populationRegulatory cytokinesNecrosis factorAntigen expressionGamma interferonIFN-gammaI MHC
1986
Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.
Collins T, Lapierre LA, Fiers W, Strominger JL, Pober JS. Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 446-450. PMID: 3455781, PMCID: PMC322876, DOI: 10.1073/pnas.83.2.446.Peer-Reviewed Original ResearchConceptsClass II MHC antigensTumor necrosis factorClass I major histocompatibility complexI major histocompatibility complexRecombinant human tumor necrosis factorMajor histocompatibility complexHuman tumor necrosis factorHuman endothelial cellsMHC antigensSurface expressionNecrosis factorMRNA levelsHuman dermal fibroblastsEndothelial cellsClass IPresence of TNFCultured human endothelial cellsType I interferonVascular endothelial cellsMHC gene expressionMHC gene regulationDermal fibroblastsImmunoregulatory moleculesB antigensI interferon
1984
Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.
Collins T, Korman AJ, Wake CT, Boss JM, Kappes DJ, Fiers W, Ault KA, Gimbrone MA, Strominger JL, Pober JS. Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 4917-4921. PMID: 6431411, PMCID: PMC391603, DOI: 10.1073/pnas.81.15.4917.Peer-Reviewed Original ResearchConceptsAntigen expressionIFN-gammaSurface expressionClass II major histocompatibility complex antigensClass II antigen expressionImmune interferonClass II MHC antigensEndothelial cellsMajor histocompatibility complex antigensImmune accessory functionHLA-DR antigensClass II antigensHistocompatibility complex antigensVascular endothelial cellsHLA-DCDermal fibroblastsHuman endothelial cellsHLA-DRMHC antigensII antigensComplex antigensB antigensDe novo appearanceClass IIStromal cells