2020
Tumor necrosis factor receptor‐2 signaling pathways promote survival of cancer stem‐like CD133+ cells in clear cell renal carcinoma
Bradley JR, Wang J, Pacey S, Warren AY, Pober JS, Al‐Lamki R. Tumor necrosis factor receptor‐2 signaling pathways promote survival of cancer stem‐like CD133+ cells in clear cell renal carcinoma. FASEB BioAdvances 2020, 2: 126-144. PMID: 32123862, PMCID: PMC7003657, DOI: 10.1096/fba.2019-00071.Peer-Reviewed Original ResearchCancer stem-like cellsClear cell renal cell carcinomaCell survivalPromotes cell survivalCytochrome c releaseCell cycle entryMitochondrial morphological changesPI-3KTumor necrosis factor receptor 2Kinase cascadePhosphorylation of VEGFR2Stem-like cellsC releaseReactive oxygen speciesZ-VADCycle entrySignal transducerTranscription 3Cell cycleNecrostatin-1Cell deathClear cell renal carcinomaSiRNA knockdownMixed lineageCell renal cell carcinoma
1998
Activation and injury of endothelial cells by cytokines.
Pober JS. Activation and injury of endothelial cells by cytokines. Current Research In Translational Medicine 1998, 46: 159-63. PMID: 9769910.Peer-Reviewed Original ResearchConceptsJun N-terminal kinaseC-Jun/ATFNF-kappa BTRAF-2Activation of JNKNew gene expressionApoptosis of ECsProtein Rac-1Endothelial cellsAnti-apoptotic protein Bcl-2Transcription factor NF-kappa BN-terminal kinaseProtein synthesis inhibitor cycloheximideApoptotic proteins Bcl-2C-Jun synthesisFactor NF-kappa BPrimary cellular targetProtein Bcl-2CDC-42CrmA proteinKinase cascadeNF-kappa B activationHuman umbilical vein endothelial cellsAmino terminusUmbilical vein endothelial cells