2022
Immune cells and their inflammatory mediators modify beta cells and cause checkpoint inhibitor-induced diabetes
Perdigoto AL, Deng S, Du KC, Kuchroo M, Burkhardt DB, Tong A, Israel G, Robert ME, Weisberg SP, Kirkiles-Smith N, Stamatouli AM, Kluger HM, Quandt Z, Young A, Yang ML, Mamula MJ, Pober JS, Anderson MS, Krishnaswamy S, Herold KC. Immune cells and their inflammatory mediators modify beta cells and cause checkpoint inhibitor-induced diabetes. JCI Insight 2022, 7: e156330. PMID: 35925682, PMCID: PMC9536276, DOI: 10.1172/jci.insight.156330.Peer-Reviewed Original ResearchConceptsCheckpoint inhibitorsΒ-cellsPD-1/PD-L1 pathwayT-lymphocyte antigen-4PD-1 blockadePD-L1 pathwayDeath ligand 1NOD mouse modelDevelopment of diabetesHuman β-cellsAutoimmune complicationsNOD miceΒ-cell populationDeath-1Diabetes mellitusImmune infiltratesInflammatory mediatorsPancreatic inflammationPD-L1Induced diabetesLymphocytic infiltrationInflammatory cytokinesAntigen-4Immune cellsT cells
1990
Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE.
Rollins BJ, Yoshimura T, Leonard EJ, Pober JS. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. American Journal Of Pathology 1990, 136: 1229-33. PMID: 2113354, PMCID: PMC1877579.Peer-Reviewed Original ResearchConceptsMCP-1/JEIL-1 betaEndothelial cellsMonocyte chemoattractantMonocyte chemoattractant MCP-1Tumor necrosis factorChemoattractant MCP-1Accumulation of monocytesSites of inflammationMonocyte chemoattractant activityHours of treatmentHuman endothelial cellsInflammatory mediatorsMCP-1Necrosis factorIFN-gammaChemoattractant activityJE proteinChemoattractantCellsBetaHoursInducible expressionMRNALesser extent
1988
Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture.
Messadi DV, Pober JS, Murphy GF. Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture. Laboratory Investigation 1988, 58: 61-7. PMID: 3121914.Peer-Reviewed Original ResearchConceptsShort-term organ cultureHLA-DRLangerhans cellsOrgan cultureT6-positive Langerhans cellsClass II major histocompatibility antigensImmune interferonClass II major histocompatibility moleculesEpidermal dendritic cellsCutaneous immune responsesDendritic cell populationsHLA-DR expressionSkin microvascular endothelial cellsMajor histocompatibility antigensMicrovascular endothelial cellsSkin cellsNewborn human foreskinMajor histocompatibility moleculesDendritic cellsInflammatory mediatorsDQ expressionHLA-DQOrgan culture systemHistocompatibility antigensImmune response
1987
Induction and Regulation of Endothelial Gene Expression
Collins T, Pober J. Induction and Regulation of Endothelial Gene Expression. Sitzungsberichte Der Heidelberger Akademie Der Wissenschaften 1987, 155-158. DOI: 10.1007/978-3-642-83118-8_49.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEndothelial cellsEndothelial gene expressionUnderlying smooth muscle cellsGene expressionSmooth muscle cellsInflammatory mediatorsPathologic lesionsSurface phenotypeVascular intimaPathophysiological processesEndothelial liningEC gene expressionMuscle cellsBlood streamArterial wallBlood cellsVessel wall pathophysiologySecretory productsVessel wallCell surface componentsCellular componentsCellular interactionsCritical determinantCellsExpression