2023
A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells
Li X, Jiang Q, Song G, Barkestani M, Wang Q, Wang S, Fan M, Fang C, Jiang B, Johnson J, Geirsson A, Tellides G, Pober J, Jane-wit D. A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells. Nature Communications 2023, 14: 3002. PMID: 37225719, PMCID: PMC10209169, DOI: 10.1038/s41467-023-38684-2.Peer-Reviewed Original ResearchConceptsEndothelial cellsInflammasome activityMembrane attack complexCaspase-1Potential therapeutic targetChronic rejectionComplement membrane attack complexTissue inflammationNLRP3 inflammasomeTissue injuryMouse modelTherapeutic targetDependent mannerInflammationAttack complexInflammasomeHuman tissuesFlightless IInhibitory associationsSkin modelRNF34CellsHedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells
Jiang B, Wang S, Song G, Jiang Q, Fan M, Fang C, Li X, Soh C, Manes T, Cheru N, Qin L, Ren P, Jortner B, Wang Q, Quaranta E, Yoo P, Geirsson A, Davis R, Tellides G, Pober J, Jane-Wit D. Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells. Science Signaling 2023, 16: eabo3406. PMID: 36943921, PMCID: PMC10061549, DOI: 10.1126/scisignal.abo3406.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryChronic vascular inflammationT cellsNLRP3 inflammasomeVascular inflammationChronic inflammationEndothelial cellsIFN-γ responsesControl T cellsNLRP3 inflammasome activityT memory cellsAllograft vasculopathyVascular sequelaeHuman endothelial cellsCoronary arteryEffector responsesCell-autonomous roleInflammasome activityMouse modelInflammationPatient samplesVigorous recruitmentInflammasomePrimary human cellsImmune signaling
2019
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone N, Kauffman K, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson D, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz M, Pober J, Chittenden T, Tellides G, Simons M. Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature Metabolism 2019, 1: 912-926. PMID: 31572976, PMCID: PMC6767930, DOI: 10.1038/s42255-019-0102-3.Peer-Reviewed Original ResearchConceptsTGF-β signalingVascular inflammationDisease progressionPlaque growthProgressive vascular diseaseVessel wall inflammationChronic inflammatory responseSpecific therapeutic interventionsAtherosclerotic plaque growthHyperlipidemic micePlaque inflammationWall inflammationProinflammatory effectsVascular diseaseInflammatory responseVascular permeabilityAtherosclerotic plaquesAbnormal shear stressTherapeutic interventionsInflammationEndothelial TGFΒ signalingVessel wallAtherosclerosisLipid retention
2008
Chapter 2 Physiology and Pathobiology of Microvascular Endothelium
Pober J. Chapter 2 Physiology and Pathobiology of Microvascular Endothelium. 2008, 37-55. DOI: 10.1016/b978-0-12-374530-9.00002-4.Peer-Reviewed Original ResearchMicrovascular ECsVascular ECsRegulation of inflammationType II activationEarly activation eventsPlastic cell typeCell typesEndothelial dysfunctionInflammatory processAdaptive immunityChapter 2 PhysiologyBlood flowMicrovascular endotheliumVascular endotheliumBlood fluidityInflammation processEpithelial-like cellsHost defenseInflammationEntire circulatory systemCirculatory systemDysfunctionInjuryEndotheliumBlood
2006
Endothelial Cell Dysfunction, Injury and Death
Pober JS, Min W. Endothelial Cell Dysfunction, Injury and Death. Handbook Of Experimental Pharmacology 2006, 176/II: 135-156. PMID: 16999227, DOI: 10.1007/3-540-36028-x_5.Peer-Reviewed Original ResearchConceptsTumor necrosis factorCytolytic T lymphocytesEC injuryEndothelial cellsReactive oxygen speciesEndothelial cell dysfunctionMacrophage-derived cytokinesVascular endothelial cellsEndothelial dysfunctionNecrosis factorCell dysfunctionT lymphocytesInjuryCommon mediatorInflammationDysfunctionDeathOxygen speciesCytokinesLymphocytesNeutrophilsDifferent agentsBiochemical pathways
2000
Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex
May M, D'Acquisto F, Madge L, Glöckner J, Pober J, Ghosh S. Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex. Science 2000, 289: 1550-1554. PMID: 10968790, DOI: 10.1126/science.289.5484.1550.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAnti-Inflammatory Agents, Non-SteroidalCells, CulturedCOS CellsEndothelium, VascularE-SelectinGene Expression RegulationHeLa CellsHumansI-kappa B KinaseInflammationMiceMice, Inbred C57BLMolecular Sequence DataMutationNF-kappa BPeptidesPoint MutationProtein Serine-Threonine KinasesProtein Structure, TertiaryRecombinant Fusion ProteinsConceptsNF-kappaBBasal NF-kappaB activityExperimental mouse modelTranscription factor nuclear factorCytokine-induced NF-kappaB activationCell-permeable NBD peptideInhibitor of kappaBNF-κB activationNF-kappaB activityNF-kappaB activationAssociation of NEMOIKK complexAcute inflammationDevelopment of drugsProinflammatory activationInflammatory responseNBD peptideMouse modelProinflammatory stimuliIκB kinase (IKK) complexNuclear factorRegulatory protein NEMOInflammationSelective inhibitionExpression of genes
1992
Recent Insights into the Mechanisms of Vascular Injury
Cotran R, Pober J. Recent Insights into the Mechanisms of Vascular Injury. 1992, 183-189. DOI: 10.1007/978-1-4899-0721-9_11.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsVascular injuryPathogenesis of vasculitisForms of vasculitisSubsequent complement activationCapillary basement membraneBlood vessel wallCytoplasmic antibodiesInflammatory vasculitisWegener's granulomatosisGoodpasture's syndromePathogenetic mechanismsImmune complexesSystemic necrotizingVasculitisComplement activationInjuryEndothelial cellsHeterogeneous groupVessel wallTransplantation reactionsGranulomatosisBasement membraneInflammationSyndromePossible role
1990
Cytokine-endothelial interactions in inflammation, immunity, and vascular injury.
Cotran RS, Pober JS. Cytokine-endothelial interactions in inflammation, immunity, and vascular injury. Journal Of The American Society Of Nephrology 1990, 1: 225-35. PMID: 2104268, DOI: 10.1681/asn.v13225.Peer-Reviewed Original ResearchConceptsVascular injuryTumor necrosis factorEffects of cytokinesEndothelial adhesion moleculesLeukocyte-endothelial adhesionCytokine-induced activationSuch pathological processesSeptic shockNecrosis factorImmune responseInterleukin-1Shwartzman reactionAdhesion moleculesPathological processesCytokinesInjuryStructural alterationsBiological characteristicsPossible contributionVasculitisInflammationEndotheliumHypersensitivityImmunityImportant role
1989
Effects of cytokines on vascular endothelium: Their role in vascular and immune injury
Cotran R, Pober J. Effects of cytokines on vascular endothelium: Their role in vascular and immune injury. Kidney International 1989, 35: 969-975. PMID: 2651773, DOI: 10.1038/ki.1989.80.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEffects of cytokinesEndothelial cellsCytokine-induced effectsRenal injuryEndothelial functionImmune injuryEndothelial activationVascular toneRenal endotheliumImmune functionCell injuryVascular endotheliumCritical homeostatic functionsEndothelium participatesClinical settingHomeostatic functionsTranscapillary permeabilityCytokinesInjurySpecific alterationsInflammationControl of proliferationHematopoietic cellsEndotheliumRecent studiesEndothelial Activation and Inflammation
Cotran R, Pober J. Endothelial Activation and Inflammation. 1989, 747-753. DOI: 10.1007/978-3-642-83755-5_101.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements