1990
Tumor necrosis factor and immune interferon synergistically increase transcription of HLA class I heavy- and light-chain genes in vascular endothelium.
Johnson DR, Pober JS. Tumor necrosis factor and immune interferon synergistically increase transcription of HLA class I heavy- and light-chain genes in vascular endothelium. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 5183-5187. PMID: 2164225, PMCID: PMC54286, DOI: 10.1073/pnas.87.13.5183.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCell NucleusCells, CulturedDrug SynergismEndothelium, VascularFlow CytometryGenes, MHC Class IHistocompatibility Antigens Class IHumansInterferon Type IInterferon-gammaMacromolecular SubstancesMolecular Sequence DataReceptors, Cell SurfaceReceptors, Tumor Necrosis FactorRecombinant ProteinsRNA, MessengerSequence Homology, Nucleic AcidTranscription, GeneticTumor Necrosis Factor-alphaConceptsNecrosis factorHuman endothelial cellsEndothelial cellsClass IInterferon gammaImmune interferonMRNA levelsMajor histocompatibility complex moleculesTumor necrosis factorHLA class IClass I major histocompatibility complex moleculesCultured human endothelial cellsHistocompatibility complex moleculesUntreated endothelial cellsSynergistic increase
1988
Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture.
Messadi DV, Pober JS, Murphy GF. Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture. Laboratory Investigation 1988, 58: 61-7. PMID: 3121914.Peer-Reviewed Original ResearchConceptsShort-term organ cultureHLA-DRLangerhans cellsOrgan cultureT6-positive Langerhans cellsClass II major histocompatibility antigensImmune interferonClass II major histocompatibility moleculesEpidermal dendritic cellsCutaneous immune responsesDendritic cell populationsHLA-DR expressionSkin microvascular endothelial cellsMajor histocompatibility antigensMicrovascular endothelial cellsSkin cellsNewborn human foreskinMajor histocompatibility moleculesDendritic cellsInflammatory mediatorsDQ expressionHLA-DQOrgan culture systemHistocompatibility antigensImmune response
1986
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
Pober JS, Gimbrone MA, Lapierre LA, Mendrick DL, Fiers W, Rothlein R, Springer TA. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. The Journal Of Immunology 1986, 137: 1893-6. PMID: 3091693, DOI: 10.4049/jimmunol.137.6.1893.Peer-Reviewed Original ResearchConceptsTumor necrosis factorIFN-gammaHuman umbilical vein endothelialNecrosis factorIL-1Interleukin-1HUVE cellsImmune interferonIntercellular adhesion molecule-1Endothelial cellsDifferent immune mediatorsAdhesion molecule-1Murine monoclonal antibodiesHuman endothelial cellsImmune mediatorsPattern of activationActivation antigensAntigenic modulationB antigensDifferent lymphokinesMolecule-1Monoclonal antibodiesProgressive increaseInterferonAntigenRecombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers.
Stolpen AH, Guinan EC, Fiers W, Pober JS. Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers. American Journal Of Pathology 1986, 123: 16-24. PMID: 2421578, PMCID: PMC1888144.Peer-Reviewed Original ResearchConceptsRecombinant tumor necrosis factorHuman endothelial cellsTumor necrosis factorNecrosis factorMorphologic changesRecombinant immune interferonSimilar morphologic changesUnique morphologic changesVascular endothelial cell monolayersVascular responsesEndothelial cell monolayersPrimary human endothelial cellsEndothelial cell morphologyVascular liningConfluent primary culturesEpithelioid organizationImmune interferonEndothelial cellsSpinelike processesPrimary cultures
1985
Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones.
Umetsu DT, Pober JS, Jabara HH, Fiers W, Yunis EJ, Burakoff SJ, Reiss CS, Geha RS. Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones. Journal Of Clinical Investigation 1985, 76: 254-260. PMID: 3160726, PMCID: PMC423759, DOI: 10.1172/jci111955.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsTetanus toxoidProliferative responseClassical antigen-presenting cellsAntigen-specific proliferative responsesAntigen-specific T cell clonesHLA-DR antigensHelper T cellsTetanus toxoid antigenT cell proliferationT cell clonesHuman dermal fibroblastsPresent tetanus toxoidMonoclonal antibody OKM1Cultured human dermal fibroblastsDermal fibroblastsLeu-M1DR expressionHLA-DRUbiquitous cell typeAntigen presentationT cellsToxoid antigenSephadex G10 columnImmune interferon
1984
Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens
Pober JS, Gimbrone MA, Collins T, Cotran RS, Ault KA, Fiers W, Krensky AM, Clayberger C, Reiss C, Burakoff SJ. Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens. Immunobiology 1984, 168: 483-494. PMID: 6397428, DOI: 10.1016/s0171-2985(84)80132-1.Peer-Reviewed Original ResearchConceptsClass II antigensVascular endothelial cellsMajor histocompatibility complexII antigensT cellsClass II moleculesHuman vascular endothelial cellsActivated T cellsEndothelial cellsStromal cellsImmune interferonT lymphocytesAntigen-specific T cellsPeripheral blood T lymphocytesClass IHelper T cell clonesImmune accessory functionNon-MHC antigensWithdrawal of interferonClass II major histocompatibility complexCultured human vascular endothelial cellsT cell responsesVascular smooth muscle cellsBlood T lymphocytesHuman class II antigensImmune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.
Collins T, Korman AJ, Wake CT, Boss JM, Kappes DJ, Fiers W, Ault KA, Gimbrone MA, Strominger JL, Pober JS. Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 4917-4921. PMID: 6431411, PMCID: PMC391603, DOI: 10.1073/pnas.81.15.4917.Peer-Reviewed Original ResearchConceptsAntigen expressionIFN-gammaSurface expressionClass II major histocompatibility complex antigensClass II antigen expressionImmune interferonClass II MHC antigensEndothelial cellsMajor histocompatibility complex antigensImmune accessory functionHLA-DR antigensClass II antigensHistocompatibility complex antigensVascular endothelial cellsHLA-DCDermal fibroblastsHuman endothelial cellsHLA-DRMHC antigensII antigensComplex antigensB antigensDe novo appearanceClass IIStromal cells
1983
Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon
Pober J, Collins T, Gimbrone M, Cotran R, Gitlin J, Fiers W, Clayberger C, Krensky A, Burakoff S, Reiss C. Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Nature 1983, 305: 726-729. PMID: 6415484, DOI: 10.1038/305726a0.Peer-Reviewed Original ResearchConceptsCytolytic T lymphocytesRecombinant immune interferonIa antigensT cellsIa expressionAlloreactive cytolytic T lymphocytesClass II major histocompatibility complex antigensT-lymphocyte-mediated responsesImmune interferonEndothelial cellsMajor histocompatibility complex antigensForeign class IHistocompatibility complex antigensHuman vascular endothelialHuman umbilical vein endothelial cellsHUVE cellsCapillary endothelial cellsUmbilical vein endothelial cellsHuman T cellsImmunological cell typesAllograft rejectionVein endothelial cellsOrgan graftsT lymphocytesComplex antigensIa expression by vascular endothelium is inducible by activated T cells and by human gamma interferon.
Pober JS, Gimbrone MA, Cotran RS, Reiss CS, Burakoff SJ, Fiers W, Ault KA. Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon. Journal Of Experimental Medicine 1983, 157: 1339-1353. PMID: 6403654, PMCID: PMC2186979, DOI: 10.1084/jem.157.4.1339.Peer-Reviewed Original ResearchConceptsAllogeneic T cellsT cellsIa antigensEndothelial cellsPeripheral blood mononuclear cellsBlood mononuclear cellsCultured human umbilical vein endothelial cellsExpression of IaActivated T cellsHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsAllograft rejectionVein endothelial cellsGamma interferon geneFluorescence flow cytometryHuman gamma interferonMononuclear cellsImmune responseGamma interferonVascular endotheliumIa expressionFlow cytometryImmune interferonMonoclonal antibodiesAntigen