Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.
Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, Gimbrone MA. Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. Journal Of Clinical Investigation 1985, 76: 2003-2011. PMID: 3877078, PMCID: PMC424265, DOI: 10.1172/jci112200.Peer-Reviewed Original ResearchConceptsEndothelial-leukocyte adhesionHuman vascular endotheliumIL-1Leukocyte adhesionVascular endotheliumCultured human vascular endotheliumLeukocyte-vessel wall interactionsIL-1 pretreatmentEndothelial cell damageEndothelial monolayersSites of inflammationIL-1 treatmentHuman umbilical vein endothelial monolayersCertain vascular diseasesPromyelocytic cell line HL-60Polymorphonuclear leukocyte adhesionIL-1 inductionImmune mediatorsHuman endothelial cellsEndothelial adhesivityVascular diseaseBlood leukocytesInterleukin-1Leukocyte cell linesCell line U937