Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.
Collins T, Lapierre LA, Fiers W, Strominger JL, Pober JS. Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 446-450. PMID: 3455781, PMCID: PMC322876, DOI: 10.1073/pnas.83.2.446.Peer-Reviewed Original ResearchConceptsClass II MHC antigensTumor necrosis factorClass I major histocompatibility complexI major histocompatibility complexRecombinant human tumor necrosis factorMajor histocompatibility complexHuman tumor necrosis factorHuman endothelial cellsMHC antigensSurface expressionNecrosis factorMRNA levelsHuman dermal fibroblastsEndothelial cellsClass IPresence of TNFCultured human endothelial cellsType I interferonVascular endothelial cellsMHC gene expressionMHC gene regulationDermal fibroblastsImmunoregulatory moleculesB antigensI interferon