2007
Activation of Transcription Factor PPARgamma In Vivo Protects Against Alloreactive Vascular Remodeling of Human Artery
Kawikova I, Tai Y, Lorber M, Tellides G, Pober J, Bothwell A. Activation of Transcription Factor PPARgamma In Vivo Protects Against Alloreactive Vascular Remodeling of Human Artery. Clinical Immunology 2007, 123: s175-s176. DOI: 10.1016/j.clim.2007.03.141.Peer-Reviewed Original Research
2000
Interferon-γ elicits arteriosclerosis in the absence of leukocytes
Tellides G, Tereb D, Kirkiles-Smith N, Kim R, Wilson J, Schechner J, Lorber M, Pober J. Interferon-γ elicits arteriosclerosis in the absence of leukocytes. Nature 2000, 403: 207-211. PMID: 10646607, DOI: 10.1038/35003221.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsArteriosclerosisCell DivisionCells, CulturedCoronary VesselsHistocompatibility AntigensHumansImage Processing, Computer-AssistedImmunohistochemistryInterferon-gammaLeukocytesMiceMice, SCIDMuscle, Smooth, VascularPlatelet-Derived Growth FactorReceptor, Platelet-Derived Growth Factor betaSwineTransplantation, HeterologousConceptsVascular smooth muscle cellsGraft arteriosclerosisIntimal expansionAbsence of leukocytesLesions of atherosclerosisSmooth muscle cellsAllogeneic transplantationArteriosclerotic changesAtheroma formationCytokine interferonExogenous IFNAntigen presentationT cellsImmunodeficient miceMononuclear leukocytesMouse modelArterial intimaIFNMuscle cellsArteriosclerosisLeukocytesHuman arteriesAtherosclerosisCellsTransplantation
1999
HUMAN ALLOGENEIC VASCULAR REJECTION AFTER ARTERIAL TRANSPLANTATION AND PERIPHERAL LYMPHOID RECONSTITUTION IN SEVERE COMBINED IMMUNODEFICIENT MICE1
Lorber MI, Wilson JH, Robert ME, Schechner JS, Kirkiles N, Qian HY, Askenase PW, Tellides G, Pober JS. HUMAN ALLOGENEIC VASCULAR REJECTION AFTER ARTERIAL TRANSPLANTATION AND PERIPHERAL LYMPHOID RECONSTITUTION IN SEVERE COMBINED IMMUNODEFICIENT MICE1. Transplantation 1999, 67: 897-903. PMID: 10199740, DOI: 10.1097/00007890-199903270-00018.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsHuman peripheral blood mononuclear cellsHuman CD3Vascular rejectionTransplantation modelAllogeneic human peripheral blood mononuclear cellsAllogeneic peripheral blood mononuclear cellsHuman dermal microvesselsBlood mononuclear cellsHuman arteriesSmooth muscle alpha-actinSmooth muscle cellsMuscle alpha-actinArterial transplantationPerforin stainingAllograft rejectionAlloimmune injuryDR antibodiesLymphocyte engraftmentMedial necrosisHLA-DRLymphocytic infiltrationLymphoid infiltrationControl miceInfrarenal aorta
1991
Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells.
Salomon RN, Hughes CC, Schoen FJ, Payne DD, Pober JS, Libby P. Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells. American Journal Of Pathology 1991, 138: 791-8. PMID: 2012171, PMCID: PMC1886118.Peer-Reviewed Original ResearchConceptsHuman cardiac allograftsCoronary arteryT lymphocytesCardiac allograftsEndothelial cellsT cellsChronic immune reactionsDonor coronary arteriesRecipient T lymphocytesRegional immune responsesClass II major histocompatibility complexGraft endothelial cellsSmooth muscle cell proliferationAllogeneic T cellsAbility of HLAHuman arteriesLong-term survivalMuscle cell proliferationCoronary arterial endotheliumMajor histocompatibility complexNormal human arteriesTypical atherosclerosisOcclusive diseaseHLA-DRTransplanted hearts