2023
Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis
Egozi A, Olaloye O, Werner L, Silva T, McCourt B, Pierce R, An X, Wang F, Chen K, Pober J, Shouval D, Itzkovitz S, Konnikova L. Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis. PLOS Biology 2023, 21: e3002124. PMID: 37205711, PMCID: PMC10234541, DOI: 10.1371/journal.pbio.3002124.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingSingle-cell atlasEpithelial cellsCell identityRNA sequencingBulk transcriptomicsCellular dysregulationAberrant interactionsNeonatal small intestinePotential targetCellular changesBiomarker discoveryGastrointestinal complicationsPremature infantsProinflammatory macrophagesProinflammatory genesClonal expansionT cellsEndothelial cellsImmune interactionsIntestinal tissueCellsSmall intestineComprehensive viewNEC
2020
Signaling through tumor necrosis receptor 2 induces stem cell marker in CD133+ regenerating tubular epithelial cells in acute cell‐mediated rejection of human renal allografts
Bradley JR, Wang J, Bardsley V, Broecker V, Thiru S, Pober JS, Al‐Lamki R. Signaling through tumor necrosis receptor 2 induces stem cell marker in CD133+ regenerating tubular epithelial cells in acute cell‐mediated rejection of human renal allografts. American Journal Of Transplantation 2020, 20: 2380-2391. PMID: 32167668, DOI: 10.1111/ajt.15846.Peer-Reviewed Original Research
2008
Human hepatic stellate cells and hepatocyte co‐cultures maintain differentiation in vitro and in vivo
Harding M, Barnaeva E, Bustamante M, Lepus C, Rahner C, Pober J, Sjogren M, Rojkind M. Human hepatic stellate cells and hepatocyte co‐cultures maintain differentiation in vitro and in vivo. The FASEB Journal 2008, 22: 465.3-465.3. DOI: 10.1096/fasebj.22.1_supplement.465.3.Peer-Reviewed Original ResearchHepatic stellate cellsStellate cellsChronic drug toxicityHuman hepatic stellate cellsSCID/bg miceLong-term toxicityBile duct-like structuresDuct-like structuresHepatitis infectionCK19 mRNAMature human hepatocytesBg miceLiver pathogensAbdominal wallDrug toxicityExpression of albuminLiver repopulationNewborn subjectsΑ-fetoproteinEpithelial cellsHuman hepatocytesΑ1-antitrypsinLong-term cultureSca-1Vivo
2001
Expression of Tumor Necrosis Factor Receptors in Normal Kidney and Rejecting Renal Transplants
Al-Lamki R, Wang J, Skepper J, Thiru S, Pober J, Bradley J. Expression of Tumor Necrosis Factor Receptors in Normal Kidney and Rejecting Renal Transplants. Laboratory Investigation 2001, 81: 1503-1515. PMID: 11706058, DOI: 10.1038/labinvest.3780364.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAntigens, CDColoring AgentsEosine Yellowish-(YS)Fluorescent DyesGene ExpressionGraft RejectionHematoxylinHumansKidneyKidney Failure, ChronicKidney TransplantationMicroscopy, ImmunoelectronReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IITumor Necrosis Factor-alphaConceptsDistal convoluted tubuleNormal kidneyTubular epithelial cellsTNFR-1Renal transplantEpithelial cellsTNFR-2Acute cellular rejectionTNFR-1 expressionAcute transplant rejectionTumor necrosis factor receptorEndothelium of glomeruliNecrosis factor receptorInteraction of TNFAcute rejectionCellular rejectionTNFR expressionTransplant rejectionCultured cellsConvoluted tubulesRenal kidneyTNF receptorTNFKidneyHuman kidney