1987
Cultured human endothelial cells express platelet-derived growth factor A chain.
Collins T, Pober JS, Gimbrone MA, Hammacher A, Betsholtz C, Westermark B, Heldin CH. Cultured human endothelial cells express platelet-derived growth factor A chain. American Journal Of Pathology 1987, 126: 7-12. PMID: 2433948, PMCID: PMC1899550.Peer-Reviewed Original ResearchConceptsRNA speciesSame relative abundanceHuman endothelial cellsRelative abundanceB polypeptide chainsEndothelial cellsChain transcriptsC-sis geneB-chain transcriptsPlatelet-derived growth factorExtensive structural dataTranscript speciesCultured human umbilical vein endothelial cellsB-chain expressionBovine aortic endothelial cellsHuman umbilical vein endothelial cellsDimeric proteinUmbilical vein endothelial cellsCultured vascular endothelial cellsDifferent genesPrincipal cell typesHybridization analysisPolypeptide chainVein endothelial cellsCell types
1986
Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome.
Leung DY, Geha RS, Newburger JW, Burns JC, Fiers W, Lapierre LA, Pober JS. Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome. Journal Of Experimental Medicine 1986, 164: 1958-1972. PMID: 3491174, PMCID: PMC2188474, DOI: 10.1084/jem.164.6.1958.Peer-Reviewed Original ResearchConceptsAcute Kawasaki syndromeTumor necrosis factorKawasaki syndromeHuman endothelial cellsIL-1Cytotoxic antibodiesImmune activationEndothelial cellsNecrosis factorTarget antigenComplement-dependent cytotoxic activityAcute febrile illnessEndothelial cell antigensVascular smooth muscle cellsAge-matched controlsMonocytes/macrophagesSmooth muscle cellsCultured vascular endothelial cellsVascular endothelial cellsComplement-mediated killingDiffuse vasculitisConvalescent phaseFebrile illnessAcute phaseVascular injury