2023
Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4+ T cells
Wang S, Song G, Barkestani M, Tobiasova Z, Wang Q, Jiang Q, Lopez R, Adelekan-Kamara Y, Fan M, Pober J, Tellides G, Jane-wit D. Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4+ T cells. Frontiers In Immunology 2023, 14: 1248027. PMID: 37915586, PMCID: PMC10616247, DOI: 10.3389/fimmu.2023.1248027.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryHuman skin xenograftsSkin xenograftsT cellsPolyfunctional cytokine responsesSolid organ transplantationT cell subsetsResponse of CD4Expression of ICOST cell populationsHumanized mouse modelPeripheral helper cellsAllograft lossIL-21PD-1Reperfusion injuryCytokine responsesVascular inflammationPolyclonal expansionHelper cellsOrgan transplantationMouse modelClinical problemCostimulatory signalsDistinct subsets
1996
Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T Cells CONVERGENCE OF COSTIMULATORY SIGNALS AND DIFFERENCES FROM TRANSFORMED T CELLS (∗)
Hughes C, Pober J. Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T Cells CONVERGENCE OF COSTIMULATORY SIGNALS AND DIFFERENCES FROM TRANSFORMED T CELLS (∗). Journal Of Biological Chemistry 1996, 271: 5369-5377. PMID: 8621390, DOI: 10.1074/jbc.271.10.5369.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBinding SitesB-LymphocytesCD3 ComplexCell Line, TransformedCell NucleusCells, CulturedFlow CytometryGene Expression RegulationHumansInterleukin-2KineticsLuciferasesLymphocyte ActivationMolecular Sequence DataNF-kappa BPromoter Regions, GeneticRecombinant ProteinsRegulatory Sequences, Nucleic AcidSignal TransductionT-LymphocytesTranscription FactorsTranscription, GeneticTransfectionTumor Cells, CulturedConceptsNormal T cellsT cellsCostimulatory signalsDifferent costimulatory signalsT cell receptorActivated T-cells (NFAT) sitesNormal human T cellsHuman T cellsT cell sitesTransformed T cellsCD2 antibodiesNF-kappaB siteAccessory cellsTumor cell linesCell receptorInterleukin-2 geneNuclear factorPrimary activationIL-2 promoterJurkat T cellsProximal AP-1 siteCell linesAntibodiesAP-1 siteTranscriptional regulation
1993
Costimulation of peripheral blood T cell activation by human endothelial cells. Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1.
Hughes CC, Pober JS. Costimulation of peripheral blood T cell activation by human endothelial cells. Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1. The Journal Of Immunology 1993, 150: 3148-60. PMID: 8468462, DOI: 10.4049/jimmunol.150.8.3148.Peer-Reviewed Original ResearchConceptsC-fos mRNAIL-2 transcriptionNuclear factorT cellsTranscription factor AP-1PHA activationPeripheral blood T cell activationAP-1Blood T cell activationFactor AP-1C-fosC-JunIL-2 productionHuman umbilical vein ECT cell activationIL-2 mRNAC-Fos proteinEC costimulationEndothelial cells (EC) actAllograft rejectionHuman endothelial cellsIL-2 regulationCostimulatory signalsCell activationKey molecular mechanisms
1990
The potential roles of vascular endothelium in immune reactions
Pober J, Doukas J, Hughes C, Savage C, Munro J, Cotran R. The potential roles of vascular endothelium in immune reactions. Human Immunology 1990, 28: 258-262. PMID: 2190954, DOI: 10.1016/0198-8859(90)90027-m.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCell-mediated immune reactionsT cellsImmune reactionsEndothelial cellsFunctional T cell activationClass II major histocompatibility complex moleculesImmune accessory functionAntigen-specific CD4Helper T cellsAntigen presenting cellsDevelopment of inflammationMajor histocompatibility complex moleculesBlood-derived leukocytesImmune accessory cellsCell typesT cell activationHistocompatibility complex moleculesVascular endothelial cellsSpecific CD4Inflammatory infiltrateVascular responsesPresenting cellsForeign antigensVascular endotheliumCostimulatory signals