Tumor necrosis factor receptor‐2 signaling pathways promote survival of cancer stem‐like CD133+ cells in clear cell renal carcinoma
Bradley JR, Wang J, Pacey S, Warren AY, Pober JS, Al‐Lamki R. Tumor necrosis factor receptor‐2 signaling pathways promote survival of cancer stem‐like CD133+ cells in clear cell renal carcinoma. FASEB BioAdvances 2020, 2: 126-144. PMID: 32123862, PMCID: PMC7003657, DOI: 10.1096/fba.2019-00071.Peer-Reviewed Original ResearchCancer stem-like cellsClear cell renal cell carcinomaCell survivalPromotes cell survivalCytochrome c releaseCell cycle entryMitochondrial morphological changesPI-3KTumor necrosis factor receptor 2Kinase cascadePhosphorylation of VEGFR2Stem-like cellsC releaseReactive oxygen speciesZ-VADCycle entrySignal transducerTranscription 3Cell cycleNecrostatin-1Cell deathClear cell renal carcinomaSiRNA knockdownMixed lineageCell renal cell carcinoma