2001
Human Endothelial Cell Presentation of Antigen and the Homing of Memory/Effector T Cells to Skin
POBER J, KLUGER M, SCHECHNER J. Human Endothelial Cell Presentation of Antigen and the Homing of Memory/Effector T Cells to Skin. Annals Of The New York Academy Of Sciences 2001, 941: 12-25. PMID: 11594565, DOI: 10.1111/j.1749-6632.2001.tb03706.x.Peer-Reviewed Original ResearchConceptsDermal endothelial cellsEffector T cell populationsMicrovascular endothelial cellsMemory T cellsT cell populationsT cellsDermal microvascular endothelial cellsEndothelial cellsE-selectinMemory/effector T cellsAntigen-specific inflammatory responsesHuman dermal endothelial cellsAdhesion moleculesEndothelial cell presentationEffector T cellsT cell recruitmentCutaneous immune reactionsClass II MHC moleculesHours of challengeAntigen-independent mannerVCAM-1 expressionCell populationsHuman dermal microvascular endothelial cellsCultured human endothelial cellsLeukocyte adhesion molecules
1993
HUMAN CD4+ T CELLS PROLIFERATE TO HLA-DR+ ALLOGENEIC VASCULAR ENDOTHELIUM
SAVAGE C, HUGHES C, MCINTYRE B, PICARD J, POBER J. HUMAN CD4+ T CELLS PROLIFERATE TO HLA-DR+ ALLOGENEIC VASCULAR ENDOTHELIUM. Transplantation 1993, 56: 128-134. PMID: 7687392, DOI: 10.1097/00007890-199307000-00024.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigens, CDAntigens, Differentiation, T-LymphocyteCD2 AntigensCD4 AntigensCD58 AntigensCells, CulturedEndothelium, VascularFlow CytometryHistocompatibility Antigens Class IHLA-DR AntigensHumansInterferon-gammaLymphocyte ActivationMembrane GlycoproteinsPolymerase Chain ReactionReceptors, ImmunologicRecombinant ProteinsT-Lymphocyte SubsetsTransplantation, HomologousUmbilical VeinsConceptsHLA-DR expressing cellsT cellsHLA-DRPolymerase chain reactionEC culturesAllogeneic class II MHC moleculesMHC moleculesLFA-1 beta chainLFA-1Peripheral blood CD4VLA-4 alphaMHC class II moleculesT cell responsesClass II MHC moleculesT cell surface moleculesT cell proliferationClass I MHC moleculesExpressing cellsClass II moleculesBeta chainII MHC moleculesDe novo expressionI MHC moleculesAllogeneic proliferationBlood CD4Four different classes of inhibitors of receptor-mediated endocytosis decrease tumor necrosis factor-induced gene expression in human endothelial cells.
Bradley JR, Johnson DR, Pober JS. Four different classes of inhibitors of receptor-mediated endocytosis decrease tumor necrosis factor-induced gene expression in human endothelial cells. The Journal Of Immunology 1993, 150: 5544-55. PMID: 8390537, DOI: 10.4049/jimmunol.150.12.5544.Peer-Reviewed Original ResearchConceptsIFN-gamma-mediated inductionELAM-1Human endothelial cellsEndothelial cellsMHC moleculesReceptor-mediated endocytosisCytokine-inducible moleculesAnti-inflammatory therapyIL-1-induced increaseClass II MHC moleculesICAM-1 expressionClass I MHC moleculesVCAM-1 expressionCultured human endothelial cellsII MHC moleculesI MHC moleculesNew potential targetsICAM-1VCAM-1Levels of mRNADensity lipoproteinExposure of cellsTNFGene expressionTNF induction