1994
Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells.
Epperson DE, Pober JS. Antigen-presenting function of human endothelial cells. Direct activation of resting CD8 T cells. The Journal Of Immunology 1994, 153: 5402-12. PMID: 7989746, DOI: 10.4049/jimmunol.153.12.5402.Peer-Reviewed Original ResearchConceptsCD8 T cellsMemory CD8 T cellsT cell proliferative responsesAllogeneic endothelial cellsCell proliferative responsesT cellsAdhesion molecule-1Endothelial cellsCD8/IL-2Proliferative responseMolecule-1CD4 T cell proliferative responsesLate activation Ag-4Human CD8 T cellsVascular cell adhesion molecule-1Class II MHC expressionIntercellular adhesion molecule-1Cell adhesion molecule-1CD4 T cellsIFN-gamma secretionOrgan graft rejectionIL-2R alpha subunitIntercellular adhesion molecule-2CD8 cells
1990
Lymphocyte-mediated activation of cultured endothelial cells (EC). CD4+ T cells inhibit EC class II MHC expression despite secreting IFN-gamma and increasing EC class I MHC and intercellular adhesion molecule-1 expression.
Doukas J, Pober JS. Lymphocyte-mediated activation of cultured endothelial cells (EC). CD4+ T cells inhibit EC class II MHC expression despite secreting IFN-gamma and increasing EC class I MHC and intercellular adhesion molecule-1 expression. The Journal Of Immunology 1990, 145: 1088-98. PMID: 1974272, DOI: 10.4049/jimmunol.145.4.1088.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, Differentiation, T-LymphocyteCD4 AntigensCD4-Positive T-LymphocytesCD8 AntigensCell Adhesion MoleculesCells, CulturedEndothelium, VascularHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansImmune SeraInterferon-gammaPhytohemagglutininsT-Lymphocytes, RegulatoryConceptsClass II MHC expressionIntercellular adhesion molecule-1 expressionClass I MHCAdhesion molecule-1 expressionClass II AgClass II expressionMolecule-1 expressionT cellsMHC expressionIFN-gammaI MHCEndothelial cellsICAM-1Class II MHC inductionClass IClass II MHC AgCoculture of CD4Failure of CD4Immunoreactive IFN-gammaICAM-1 expressionClass II MHCCultured endothelial cellsUnfractionated PBLTime of inductionMHC induction