2023
Transendothelial Migration of Human B Cells: Chemokine versus Antigen.
Wang V, Pober J, Manes T. Transendothelial Migration of Human B Cells: Chemokine versus Antigen. The Journal Of Immunology 2023, 211: 923-931. PMID: 37530585, PMCID: PMC10529164, DOI: 10.4049/jimmunol.2200887.Peer-Reviewed Original ResearchConceptsB cellsLeukocyte cell adhesion moleculeTransendothelial migrationEndothelial cellsCell adhesion moleculeAdhesion moleculesPeripheral blood CD19B cell subsetsMemory B cellsInnate immune propertiesSites of inflammationMicrovascular endothelial cellsHuman microvascular endothelial cellsHuman B cellsBlood CD19Peripheral bloodCell subsetsVenular flowT cellsICAM-1VCAM-1Immune propertiesSyk activationChemokinesExpression of genes
2014
Polarized Granzyme Release Is Required for Antigen-Driven Transendothelial Migration of Human Effector Memory CD4 T Cells
Manes TD, Pober JS. Polarized Granzyme Release Is Required for Antigen-Driven Transendothelial Migration of Human Effector Memory CD4 T Cells. The Journal Of Immunology 2014, 193: 5809-5815. PMID: 25367116, PMCID: PMC4258477, DOI: 10.4049/jimmunol.1401665.Peer-Reviewed Original ResearchConceptsEffector memory CD4 T cellsMemory CD4 T cellsCD4 T cellsT cellsTransendothelial migrationImmune synapse formationEndothelial cell monolayersInflammatory chemokinesMorphologic manifestationsGranzyme releaseSynapse formationTCR recognitionGranule dischargeDynein-driven transportChemokinesCell monolayersEarly eventsEndotheliumCytosolic granulesCellsMTOC reorientationProteolytic activityMicrotubule organizing centerMolecular requirementsGranule function