2024
Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation
Al-Lamki R, Tolkovsky A, Alawwami M, Lu W, Field S, Wang J, Pober J, Bradley J. Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation. American Journal Of Pathology 2024, 194: 1374-1387. PMID: 38537932, DOI: 10.1016/j.ajpath.2024.02.019.Peer-Reviewed Original ResearchClear cell renal cell carcinomaCell cycle entryTumor necrosis factorSignaling pathwayTumor cellsTNFR2 signaling pathwayCell surface receptorsIncreased cell deathSecrete tumor necrosis factorCell cycle activitySerine 65Cell renal cell carcinomaPhosphorylation of 4EBP1Renal cell carcinomaInhibition of mTORGene translationSelective ligationMitochondrial functionCell deathDownstream targetsPharmacological inhibition of mTORClear cell renal cell carcinoma tissuesSurface receptorsPI3KEpithelial malignancies
2022
Co-Expression and Functional Interactions of Death Receptor 3 and E-Selectin in Clear Cell Renal Cell Carcinoma
Al-Lamki RS, Wang J, Pober JS, Bradley JR. Co-Expression and Functional Interactions of Death Receptor 3 and E-Selectin in Clear Cell Renal Cell Carcinoma. American Journal Of Pathology 2022, 192: 722-736. PMID: 35063404, DOI: 10.1016/j.ajpath.2021.12.010.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseCell cycle entryCcRCC cellsDeath receptor 3Protein kinaseClear cell renal cell carcinoma cellsProximity ligation assayRenal cell carcinoma cellsReceptor 3E-selectinPotential new targetsCycle entryNF-κB-dependent mannerNF-κBLigation assayTumor gradeCcRCC tissuesFunctional interactionSelectin expressionFunctional roleClear cell renal cell carcinomaOrgan cultureCell renal cell carcinomaExpression increasesAddition of TL1A
2020
Tumor necrosis factor receptor‐2 signaling pathways promote survival of cancer stem‐like CD133+ cells in clear cell renal carcinoma
Bradley JR, Wang J, Pacey S, Warren AY, Pober JS, Al‐Lamki R. Tumor necrosis factor receptor‐2 signaling pathways promote survival of cancer stem‐like CD133+ cells in clear cell renal carcinoma. FASEB BioAdvances 2020, 2: 126-144. PMID: 32123862, PMCID: PMC7003657, DOI: 10.1096/fba.2019-00071.Peer-Reviewed Original ResearchCancer stem-like cellsClear cell renal cell carcinomaCell survivalPromotes cell survivalCytochrome c releaseCell cycle entryMitochondrial morphological changesPI-3KTumor necrosis factor receptor 2Kinase cascadePhosphorylation of VEGFR2Stem-like cellsC releaseReactive oxygen speciesZ-VADCycle entrySignal transducerTranscription 3Cell cycleNecrostatin-1Cell deathClear cell renal carcinomaSiRNA knockdownMixed lineageCell renal cell carcinoma
2009
TNF Receptors Differentially Signal and Are Differentially Expressed and Regulated in the Human Heart
Al-Lamki R, Brookes AP, Wang J, Reid MJ, Parameshwar J, Goddard MJ, Tellides G, Wan T, Min W, Pober JS, Bradley JR. TNF Receptors Differentially Signal and Are Differentially Expressed and Regulated in the Human Heart. American Journal Of Transplantation 2009, 9: 2679-2696. PMID: 19788501, PMCID: PMC3517885, DOI: 10.1111/j.1600-6143.2009.02831.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell CycleCell DeathEndothelium, VascularEnzyme ActivationGraft RejectionHeart TransplantationHumansMAP Kinase Kinase Kinase 5MiceMice, KnockoutMyocardiumMyocytes, CardiacOrgan Culture TechniquesProtein-Tyrosine KinasesReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIRNA, MessengerTumor Necrosis Factor-alphaConceptsVascular endothelial cellsCardiac allograftsCell cycle entryApoptosis signal-regulating kinase 1Cycle entryExpression of TNFTNFR1 knockoutNecrosis factorTarget cell responseTNFTNF receptorCardiac fibroblastsCell responsesSignal-regulated kinases 1TNF responseASK1 activationMyocardiumEndothelial cellsEpithelial tyrosine kinaseTNFR2Human heartOrgan cultureTNFR1Etk activationAllografts