Tumor necrosis factor is delivered to mitochondria where a tumor necrosis factor-binding protein is localized.
Ledgerwood EC, Prins JB, Bright NA, Johnson DR, Wolfreys K, Pober JS, O'Rahilly S, Bradley JR. Tumor necrosis factor is delivered to mitochondria where a tumor necrosis factor-binding protein is localized. Laboratory Investigation 1998, 78: 1583-9. PMID: 9881958.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAntibodies, MonoclonalCarrier ProteinsCells, CulturedHumansImmunohistochemistryIntracellular MembranesIodine RadioisotopesLysosomesMicroscopy, ImmunoelectronMitochondriaReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type ITumor Necrosis Factor Decoy ReceptorsTumor Necrosis Factor-alphaU937 CellsConceptsInner mitochondrial membraneExtracellular ligandsMitochondrial membraneTumor necrosis factor receptorIsolated mitochondriaBinding proteinNecrosis factor receptorMitochondriaCell surfaceImmunoelectron microscopyProteinFactor receptorSubcellular fractionsWestern blottingFactor binding proteinTNF effectsPathwayDiverse actionsExogenous TNFTNFR-IIMonoclonal antibodiesTumor necrosis factor binding proteinLysosomesTumor necrosis factorBlotting