2020
Complement activated interferon-γ-primed human endothelium transpresents interleukin-15 to CD8+ T cells
Xie CB, Jiang B, Qin L, Tellides G, Kirkiles-Smith NC, Jane-wit D, Pober JS. Complement activated interferon-γ-primed human endothelium transpresents interleukin-15 to CD8+ T cells. Journal Of Clinical Investigation 2020, 130: 3437-3452. PMID: 32191642, PMCID: PMC7324183, DOI: 10.1172/jci135060.Peer-Reviewed Original ResearchConceptsIL-15/IL-15Rα complexesIL-1βHuman endothelial cellsMembrane attack complexEndothelial cellsAcute rejectionT cellsT cell-mediated acute rejectionCell-mediated acute rejectionComplement-mediated pathologiesIL-15Rα expressionGraft endothelial cellsHuman coronary artery graftsEffector memory CD4T cell infiltrationCoronary artery graftsIL-1 receptorActive IL-1βCultured human endothelial cellsNLRP3 inflammasome assemblyNoncanonical NF-κBArtery graftAlloreactive CD8Complement membrane attack complexMemory CD4
2001
Expression of Tumor Necrosis Factor Receptors in Normal Kidney and Rejecting Renal Transplants
Al-Lamki R, Wang J, Skepper J, Thiru S, Pober J, Bradley J. Expression of Tumor Necrosis Factor Receptors in Normal Kidney and Rejecting Renal Transplants. Laboratory Investigation 2001, 81: 1503-1515. PMID: 11706058, DOI: 10.1038/labinvest.3780364.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAntigens, CDColoring AgentsEosine Yellowish-(YS)Fluorescent DyesGene ExpressionGraft RejectionHematoxylinHumansKidneyKidney Failure, ChronicKidney TransplantationMicroscopy, ImmunoelectronReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IITumor Necrosis Factor-alphaConceptsDistal convoluted tubuleNormal kidneyTubular epithelial cellsTNFR-1Renal transplantEpithelial cellsTNFR-2Acute cellular rejectionTNFR-1 expressionAcute transplant rejectionTumor necrosis factor receptorEndothelium of glomeruliNecrosis factor receptorInteraction of TNFAcute rejectionCellular rejectionTNFR expressionTransplant rejectionCultured cellsConvoluted tubulesRenal kidneyTNF receptorTNFKidneyHuman kidney
1992
Expression of vascular cell adhesion molecule-1 in human renal allografts.
Briscoe DM, Pober JS, Harmon WE, Cotran RS. Expression of vascular cell adhesion molecule-1 in human renal allografts. Journal Of The American Society Of Nephrology 1992, 3: 1180-5. PMID: 1282831, DOI: 10.1681/asn.v351180.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAntigens, CDAntigens, Differentiation, MyelomonocyticCD3 ComplexCell Adhesion MoleculesEndothelium, VascularE-SelectinGraft RejectionHumansIntercellular Adhesion Molecule-1Kidney TransplantationKidney Tubular Necrosis, AcuteKidney TubulesMacrophagesMonocytesPostoperative ComplicationsT-Lymphocyte SubsetsTransplantation, HomologousVascular Cell Adhesion Molecule-1ConceptsVascular cell adhesion molecule-1Cell adhesion molecule-1VCAM-1 expressionAdhesion molecule-1Renal allograftsNormal biopsiesMolecule-1Human renal allograft biopsiesMonocyte/macrophage infiltrateEndothelial VCAM-1 expressionAcute tubular necrosisRenal allograft biopsiesT-cell infiltratesT cell infiltrationHuman renal allograftsEndothelial VCAM-1Normal kidney specimensArea of infiltratesMean scoreVascular endothelial cellsAcute rejectionAllograft biopsiesTubular necrosisCell infiltrateClinicopathologic diagnosis
1989
Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis.
Libby P, Salomon RN, Payne DD, Schoen FJ, Pober JS. Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis. Transplantation Proceedings 1989, 21: 3677-84. PMID: 2669279.Peer-Reviewed Original ResearchConceptsArterial diseaseT cellsVascular cellsChronic immune reactionsTransplantation-associated arteriosclerosisTypical acute rejectionDelayed-type hypersensitivityHelper T cellsWall cellsClass II HLACytolytic T cellsVascular wall cellsClass I HLAVessel wall cellsUnderstanding of atherogenesisAcute rejectionGraft arteryCoronary arteriosclerosisCoronary atherosclerosisBasic pathobiologyCellular immunityImmune activationSelective therapeutic strategiesCoronary circulationAccelerated disease