2004
Pathophysiology and pharmacologic treatment of acute spinal cord injury
Kwon BK, Tetzlaff W, Grauer JN, Beiner J, Vaccaro AR. Pathophysiology and pharmacologic treatment of acute spinal cord injury. The Spine Journal 2004, 4: 451-464. PMID: 15246307, DOI: 10.1016/j.spinee.2003.07.007.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryPathophysiologic processesPharmacologic treatmentNeuroprotective agentsSecondary damageImportant pathophysiologic processSecondary injury cascadePharmacologic therapyAcute treatmentInjury cascadeNeurologic functionNeuroprotective strategiesDevastating injuriesPathophysiologic mechanismsSpecific therapyPathophysiologic eventsSpinal cordHuman trialsPotential therapyInjuryAnimal dataLiterature reviewTherapy
2003
Postoperative wound infections of the spine.
Beiner JM, Grauer J, Kwon BK, Vaccaro AR. Postoperative wound infections of the spine. Neurosurgical FOCUS 2003, 15: e14. PMID: 15347232, DOI: 10.3171/foc.2003.15.3.14.BooksMeSH KeywordsAnti-Bacterial AgentsAntibiotic ProphylaxisBlood SedimentationBone TransplantationCombined Modality TherapyComorbidityC-Reactive ProteinDebridementDiagnostic ImagingDisease SusceptibilityDiskectomyDrug Therapy, CombinationEquipment ContaminationHumansInternal FixatorsMalnutritionNutritional SupportReoperationRisk FactorsSpineSurgical Wound InfectionTherapeutic IrrigationConceptsRate of infectionLumbar surgeryWound infectionNutritional statusPostoperative spinal wound infectionsAntibiotic prophylactic therapySpinal wound infectionsPostoperative wound infectionUncomplicated postoperative courseErythrocyte sedimentation rateC-reactive proteinPossibility of infectionMajority of casesSubfascial layerProphylactic therapyAggressive treatmentPostoperative coursePatient factorsWound swellingClinical symptomsSuperficial infectionRisk factorsBone graftInfectionComplete eradication