2010
Augmented demineralized bone matrix: a potential alternative for posterolateral lumbar spinal fusion.
Biswas D, Bible JE, Whang PH, Miller CP, Jaw R, Miller S, Grauer JN. Augmented demineralized bone matrix: a potential alternative for posterolateral lumbar spinal fusion. The American Journal Of Orthopedics 2010, 39: 531-8. PMID: 21623419.Peer-Reviewed Original ResearchConceptsFusion rateGraft alternativesPosterolateral lumbar spinal fusionLumbar spinal fusionRhBMP-2Spine fusion modelDose-response curveEctopic bone formation modelBone graft alternativesStudy ratsLumbar fusionRat modelSpinal fusionSpine fusionB graftsRecombinant human bone morphogenetic protein-2Manual palpationHuman bone morphogenetic protein-2Bone matrix productsSignificant differencesProtein 2DBM carrierBone matrixAutograftBone morphogenetic protein-2
2007
rhBMP-2 (ACS and CRM Formulations) Overcomes Pseudarthrosis in a New Zealand White Rabbit Posterolateral Fusion Model
Lawrence JP, Waked W, Gillon TJ, White AP, Spock CR, Biswas D, Rosenberger P, Troiano N, Albert TJ, Grauer JN. rhBMP-2 (ACS and CRM Formulations) Overcomes Pseudarthrosis in a New Zealand White Rabbit Posterolateral Fusion Model. Spine 2007, 32: 1206-1213. PMID: 17495777, DOI: 10.1097/brs.0b013e318054721e.Peer-Reviewed Original ResearchAnimalsBone Morphogenetic Protein 2Bone Morphogenetic ProteinsBone SubstitutesBone TransplantationChemistry, PharmaceuticalDisease Models, AnimalDrug CarriersFemaleHumansIliumLumbar VertebraeNicotineOsseointegrationPseudarthrosisRabbitsRecombinant ProteinsSpinal FusionTime FactorsTomography, X-Ray ComputedTransforming Growth Factor betaTransplantation, Autologous
2001
Evaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion
Grauer J, Patel T, Erulkar J, Troiano N, Panjabi M, Friedlaender G. Evaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion. Spine 2001, 26: 127-133. PMID: 11154530, DOI: 10.1097/00007632-200101150-00004.Peer-Reviewed Original ResearchConceptsIntertransverse process lumbar fusionIntertransverse process fusionManual palpationLumbar fusionOP-1Rabbit modelAutogenous iliac crest boneProcess fusionGraft substituteNew Zealand white rabbitsIliac crest boneOP-1 groupZealand white rabbitsMultidirectional flexibility testingAutograft specimensLess morbidityBiomechanical testing resultsCrest boneStudy groupAutograft groupBACKGROUND DATAFusion massWhite rabbitsL5-L6Bone graft substitute