2008
125I-labeled OP-1 is Locally Retained in a Rabbit Lumbar Fusion Model
Erickson BP, Pierce AR, Simpson AK, Nash J, Grauer JN. 125I-labeled OP-1 is Locally Retained in a Rabbit Lumbar Fusion Model. Clinical Orthopaedics And Related Research® 2008, 466: 210-215. PMID: 18196395, PMCID: PMC2505306, DOI: 10.1007/s11999-007-0017-2.Peer-Reviewed Original Research
2006
Healos/Recombinant Human Growth and Differentiation Factor-5 Induces Posterolateral Lumbar Fusion in a New Zealand White Rabbit Model
Magit DP, Maak T, Trioano N, Raphael B, Hamouria Q, Polzhofer G, Drespe I, Albert TJ, Grauer JN. Healos/Recombinant Human Growth and Differentiation Factor-5 Induces Posterolateral Lumbar Fusion in a New Zealand White Rabbit Model. Spine 2006, 31: 2180-2188. PMID: 16946651, DOI: 10.1097/01.brs.0000232823.82106.0a.Peer-Reviewed Original ResearchConceptsRecombinant human growthDifferentiation factor 5Fusion ratePosterolateral lumbar spine fusionPosterolateral lumbar fusionIliac crest autograftLumbar spine fusionNew Zealand white rabbitsNew Zealand white rabbit modelZealand white rabbitsRabbit fusion modelWhite rabbit modelIntertransverse process fusionBone graft alternativesCrest autograftLumbar fusionBACKGROUND DATAHistologic differencesPreclinical studiesSpine fusionTreatment groupsFactor 5Histologic analysisBone graftFusion massEffect of daily parathyroid hormone (1–34) on lumbar fusion in a rat model
Lawrence JP, Ennis F, White AP, Magit D, Polzhofer G, Drespe I, Troiano NW, Grauer JN. Effect of daily parathyroid hormone (1–34) on lumbar fusion in a rat model. The Spine Journal 2006, 6: 385-390. PMID: 16825043, DOI: 10.1016/j.spinee.2005.10.010.Peer-Reviewed Original ResearchConceptsSerum osteocalcin levelsParathyroid hormoneOsteocalcin levelsFusion rateDaily injectionsManual palpationLumbar fusionRat modelIntertransverse process spinal fusionDaily parathyroid hormoneSpinal fusion outcomesPosterolateral lumbar fusionIliac crest autograftSprague-Dawley ratsPreclinical animal studiesGreater fusion rateGreat clinical valuePlacebo groupIntermittent administrationSerum osteocalcinCrest autograftAnabolic effectsSpinal fusionInjectable agentsClinical value
2005
Animal models for spinal fusion
Drespe IH, Polzhofer GK, Turner AS, Grauer JN. Animal models for spinal fusion. The Spine Journal 2005, 5: s209-s216. PMID: 16291115, DOI: 10.1016/j.spinee.2005.02.013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2004
Comparison of Posterolateral Lumbar Fusion Rates of Grafton Putty and OP-1 Putty in an Athymic Rat Model
Bomback DA, Grauer JN, Lugo R, Troiano N, Patel TCh, Friedlaender GE. Comparison of Posterolateral Lumbar Fusion Rates of Grafton Putty and OP-1 Putty in an Athymic Rat Model. Spine 2004, 29: 1612-1617. PMID: 15284503, DOI: 10.1097/01.brs.0000132512.53305.a1.Peer-Reviewed Original ResearchConceptsOP-1 PuttyFusion rateSpine fusion modelManual palpationOP-1Posterolateral lumbar spine fusionLumbar spine fusionSimilar fusion ratesAthymic nude ratsSpine fusion ratesLumbar fusion ratesAthymic rat modelIntertransverse process fusionBone graft alternativesInflammatory responseRat modelBACKGROUND DATASpine fusionStudy groupNude ratsOsteogenic protein-1Athymic ratsFusion massOsteoinductive productsGraft alternativesPosterolateral lumbar fusions in athymic rats: characterization of a model
Grauer JN, Bomback DA, Lugo R, Troiano NW, Patel TC, Friedlaender GE. Posterolateral lumbar fusions in athymic rats: characterization of a model. The Spine Journal 2004, 4: 281-286. PMID: 15125850, DOI: 10.1016/j.spinee.2003.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone TransplantationFemaleLumbar VertebraeModels, AnimalPalpationRadiographyRatsRats, NudeSpinal FusionConceptsPosterolateral lumbar fusion modelAthymic ratsManual palpationPosterolateral lumbar fusionL4-L5 levelSmall animal modelsPotential inflammatory responseLumbar fusionInflammatory responseSpinal fusionHistology resultsAutograft fusionAnimal modelsFusion rateOsteoinductive productsRatsIntertransverse fusionPalpationSurvival surgeryGraftWeeksComparison of FusionSpontaneous fusionLimited utilityXenogenic proteins
2001
Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion
Patel T, Erulkar J, Grauer J, Troiano N, Panjabi M, Friedlaender G. Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion. Spine 2001, 26: 1656-1661. PMID: 11474350, DOI: 10.1097/00007632-200108010-00004.Peer-Reviewed Original ResearchConceptsPosterolateral lumbar fusionOsteogenic protein-1Inhibitory effectProtein 1Lumbar fusionRabbit posterolateral lumbar fusion modelRabbit posterolateral spine fusion modelFusion massRabbit modelSubcutaneous mini-osmotic pumpsPosterolateral lumbar fusion modelMini-osmotic pumpsNew Zealand white rabbitsNew Zealand white rabbit modelZealand white rabbitsPosterolateral spine fusionSpine fusion modelPosterolateral intertransverse process fusionWhite rabbit modelPresence of nicotineIntertransverse process fusionBone graft alternativesBony fusionBACKGROUND DATASpine fusion