2008
125I-labeled OP-1 is Locally Retained in a Rabbit Lumbar Fusion Model
Erickson BP, Pierce AR, Simpson AK, Nash J, Grauer JN. 125I-labeled OP-1 is Locally Retained in a Rabbit Lumbar Fusion Model. Clinical Orthopaedics And Related Research® 2008, 466: 210-215. PMID: 18196395, PMCID: PMC2505306, DOI: 10.1007/s11999-007-0017-2.Peer-Reviewed Original Research
2007
rhBMP-2 (ACS and CRM Formulations) Overcomes Pseudarthrosis in a New Zealand White Rabbit Posterolateral Fusion Model
Lawrence JP, Waked W, Gillon TJ, White AP, Spock CR, Biswas D, Rosenberger P, Troiano N, Albert TJ, Grauer JN. rhBMP-2 (ACS and CRM Formulations) Overcomes Pseudarthrosis in a New Zealand White Rabbit Posterolateral Fusion Model. Spine 2007, 32: 1206-1213. PMID: 17495777, DOI: 10.1097/brs.0b013e318054721e.Peer-Reviewed Original ResearchAnimalsBone Morphogenetic Protein 2Bone Morphogenetic ProteinsBone SubstitutesBone TransplantationChemistry, PharmaceuticalDisease Models, AnimalDrug CarriersFemaleHumansIliumLumbar VertebraeNicotineOsseointegrationPseudarthrosisRabbitsRecombinant ProteinsSpinal FusionTime FactorsTomography, X-Ray ComputedTransforming Growth Factor betaTransplantation, Autologous
2006
Osteogenic Protein-1 Induced Gene Expression: Evaluation in a Posterolateral Spinal Pseudarthrosis Model
White AP, Maak TG, Prince D, Vaccaro AR, Albert TJ, Hilibrand AS, Grauer JN. Osteogenic Protein-1 Induced Gene Expression: Evaluation in a Posterolateral Spinal Pseudarthrosis Model. Spine 2006, 31: 2550-2555. PMID: 17047543, DOI: 10.1097/01.brs.0000240713.24367.42.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 7Bone Morphogenetic ProteinsGene Expression RegulationLumbar VertebraePseudarthrosisRabbitsSpinal FracturesSpinal FusionTransforming Growth Factor betaConceptsGene expressionOsteogenic protein-1Protein 1Differential gene expressionGlyceraldehyde-3-phosphate dehydrogenaseGene expression dataBone morphogenetic protein-2Morphogenetic protein-2Platelet-derived growthExpression dataTranscriptase-polymerase chain reactionPolymerase chain reactionMolecular studiesProtein 2Messenger ribonucleic acidRibonucleic acidChain reactionAdhesion moleculesCytokine gene expressionExpressionGrowth factorVascular endothelial growth factorEnhanced levelsEndothelial growth factorReverse transcriptase-polymerase chain reaction
2004
Development of a New Zealand White Rabbit Model of Spinal Pseudarthrosis Repair and Evaluation of the Potential Role of OP-1 to Overcome Pseudarthrosis
Grauer JN, Vaccaro AR, Kato M, Kwon BK, Beiner JM, Patel TC, Hilibrand AS, Chiba K, Albert TJ. Development of a New Zealand White Rabbit Model of Spinal Pseudarthrosis Repair and Evaluation of the Potential Role of OP-1 to Overcome Pseudarthrosis. Spine 2004, 29: 1405-1412. PMID: 15223930, DOI: 10.1097/01.brs.0000129028.25671.96.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 7Bone Morphogenetic ProteinsCotinineDrug Evaluation, PreclinicalFemaleHumansIliumInfusion Pumps, ImplantableLumbar VertebraeNicotinePostoperative ComplicationsPseudarthrosisRabbitsRadiographyRecombinant ProteinsSingle-Blind MethodSpinal DiseasesSpinal FusionTransforming Growth Factor betaTransplantation, AutologousWound HealingConceptsNew Zealand white rabbitsPosterolateral lumbar fusionOsteogenic protein-1Zealand white rabbitsLumbar fusionPseudarthrosis repairFusion massFusion rateWhite rabbitsManual palpationIliac crest autograftNew Zealand white rabbit modelTreatment of pseudarthrosesRabbit fusion modelWhite rabbit modelPresence of nicotineCrest autograftBACKGROUND DATAPseudarthrosesComputed tomographyAnimal modelsRabbit modelAutograftGraftWeeks
2001
Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion
Patel T, Erulkar J, Grauer J, Troiano N, Panjabi M, Friedlaender G. Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion. Spine 2001, 26: 1656-1661. PMID: 11474350, DOI: 10.1097/00007632-200108010-00004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 7Bone Morphogenetic ProteinsBone TransplantationCotinineGraft SurvivalLumbar VertebraeModels, AnimalNicotineRabbitsRadiographySpinal FusionTransforming Growth Factor betaConceptsPosterolateral lumbar fusionOsteogenic protein-1Inhibitory effectProtein 1Lumbar fusionRabbit posterolateral lumbar fusion modelRabbit posterolateral spine fusion modelFusion massRabbit modelSubcutaneous mini-osmotic pumpsPosterolateral lumbar fusion modelMini-osmotic pumpsNew Zealand white rabbitsNew Zealand white rabbit modelZealand white rabbitsPosterolateral spine fusionSpine fusion modelPosterolateral intertransverse process fusionWhite rabbit modelPresence of nicotineIntertransverse process fusionBone graft alternativesBony fusionBACKGROUND DATASpine fusionEvaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion
Grauer J, Patel T, Erulkar J, Troiano N, Panjabi M, Friedlaender G. Evaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion. Spine 2001, 26: 127-133. PMID: 11154530, DOI: 10.1097/00007632-200101150-00004.Peer-Reviewed Original ResearchConceptsIntertransverse process lumbar fusionIntertransverse process fusionManual palpationLumbar fusionOP-1Rabbit modelAutogenous iliac crest boneProcess fusionGraft substituteNew Zealand white rabbitsIliac crest boneOP-1 groupZealand white rabbitsMultidirectional flexibility testingAutograft specimensLess morbidityBiomechanical testing resultsCrest boneStudy groupAutograft groupBACKGROUND DATAFusion massWhite rabbitsL5-L6Bone graft substitute