2013
Recovery Room Radiographs Not Found to Have Incremental Utility Above Intraoperative Images After Lumbar Fusion Procedures
Bohl DD, Gruskay JA, Miller CP, Varthi A, Ruiz FK, Whang PG, Grauer JN. Recovery Room Radiographs Not Found to Have Incremental Utility Above Intraoperative Images After Lumbar Fusion Procedures. Spine 2013, 38: 1927-1933. PMID: 23883831, DOI: 10.1097/brs.0b013e3182a527be.Peer-Reviewed Original ResearchConceptsLumbar fusion proceduresLumbar interbody fusionClinical utilityRecovery roomInterbody fusionFusion proceduresSurgical constructTransforaminal lumbar interbody fusionAnterior lumbar interbody fusionAnterior-posterior fusionRetrospective case seriesPosterolateral lumbar fusionLow clinical utilityPlain film imagesRecovery room radiographsIntraoperative imagesIncremental clinical utilityCase seriesConsecutive seriesLumbar fusionBACKGROUND DATAIntraoperative fluoroscopic imagesWound closureRadiation exposureIncremental utility
2006
Healos/Recombinant Human Growth and Differentiation Factor-5 Induces Posterolateral Lumbar Fusion in a New Zealand White Rabbit Model
Magit DP, Maak T, Trioano N, Raphael B, Hamouria Q, Polzhofer G, Drespe I, Albert TJ, Grauer JN. Healos/Recombinant Human Growth and Differentiation Factor-5 Induces Posterolateral Lumbar Fusion in a New Zealand White Rabbit Model. Spine 2006, 31: 2180-2188. PMID: 16946651, DOI: 10.1097/01.brs.0000232823.82106.0a.Peer-Reviewed Original ResearchConceptsRecombinant human growthDifferentiation factor 5Fusion ratePosterolateral lumbar spine fusionPosterolateral lumbar fusionIliac crest autograftLumbar spine fusionNew Zealand white rabbitsNew Zealand white rabbit modelZealand white rabbitsRabbit fusion modelWhite rabbit modelIntertransverse process fusionBone graft alternativesCrest autograftLumbar fusionBACKGROUND DATAHistologic differencesPreclinical studiesSpine fusionTreatment groupsFactor 5Histologic analysisBone graftFusion massEffect of daily parathyroid hormone (1–34) on lumbar fusion in a rat model
Lawrence JP, Ennis F, White AP, Magit D, Polzhofer G, Drespe I, Troiano NW, Grauer JN. Effect of daily parathyroid hormone (1–34) on lumbar fusion in a rat model. The Spine Journal 2006, 6: 385-390. PMID: 16825043, DOI: 10.1016/j.spinee.2005.10.010.Peer-Reviewed Original ResearchConceptsSerum osteocalcin levelsParathyroid hormoneOsteocalcin levelsFusion rateDaily injectionsManual palpationLumbar fusionRat modelIntertransverse process spinal fusionDaily parathyroid hormoneSpinal fusion outcomesPosterolateral lumbar fusionIliac crest autograftSprague-Dawley ratsPreclinical animal studiesGreater fusion rateGreat clinical valuePlacebo groupIntermittent administrationSerum osteocalcinCrest autograftAnabolic effectsSpinal fusionInjectable agentsClinical value
2004
Development of a New Zealand White Rabbit Model of Spinal Pseudarthrosis Repair and Evaluation of the Potential Role of OP-1 to Overcome Pseudarthrosis
Grauer JN, Vaccaro AR, Kato M, Kwon BK, Beiner JM, Patel TC, Hilibrand AS, Chiba K, Albert TJ. Development of a New Zealand White Rabbit Model of Spinal Pseudarthrosis Repair and Evaluation of the Potential Role of OP-1 to Overcome Pseudarthrosis. Spine 2004, 29: 1405-1412. PMID: 15223930, DOI: 10.1097/01.brs.0000129028.25671.96.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 7Bone Morphogenetic ProteinsCotinineDrug Evaluation, PreclinicalFemaleHumansIliumInfusion Pumps, ImplantableLumbar VertebraeNicotinePostoperative ComplicationsPseudarthrosisRabbitsRadiographyRecombinant ProteinsSingle-Blind MethodSpinal DiseasesSpinal FusionTransforming Growth Factor betaTransplantation, AutologousWound HealingConceptsNew Zealand white rabbitsPosterolateral lumbar fusionOsteogenic protein-1Zealand white rabbitsLumbar fusionPseudarthrosis repairFusion massFusion rateWhite rabbitsManual palpationIliac crest autograftNew Zealand white rabbit modelTreatment of pseudarthrosesRabbit fusion modelWhite rabbit modelPresence of nicotineCrest autograftBACKGROUND DATAPseudarthrosesComputed tomographyAnimal modelsRabbit modelAutograftGraftWeeksPosterolateral lumbar fusions in athymic rats: characterization of a model
Grauer JN, Bomback DA, Lugo R, Troiano NW, Patel TC, Friedlaender GE. Posterolateral lumbar fusions in athymic rats: characterization of a model. The Spine Journal 2004, 4: 281-286. PMID: 15125850, DOI: 10.1016/j.spinee.2003.10.001.Peer-Reviewed Original ResearchConceptsPosterolateral lumbar fusion modelAthymic ratsManual palpationPosterolateral lumbar fusionL4-L5 levelSmall animal modelsPotential inflammatory responseLumbar fusionInflammatory responseSpinal fusionHistology resultsAutograft fusionAnimal modelsFusion rateOsteoinductive productsRatsIntertransverse fusionPalpationSurvival surgeryGraftWeeksComparison of FusionSpontaneous fusionLimited utilityXenogenic proteins
2001
Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion
Patel T, Erulkar J, Grauer J, Troiano N, Panjabi M, Friedlaender G. Osteogenic Protein-1 Overcomes the Inhibitory Effect of Nicotine on Posterolateral Lumbar Fusion. Spine 2001, 26: 1656-1661. PMID: 11474350, DOI: 10.1097/00007632-200108010-00004.Peer-Reviewed Original ResearchConceptsPosterolateral lumbar fusionOsteogenic protein-1Inhibitory effectProtein 1Lumbar fusionRabbit posterolateral lumbar fusion modelRabbit posterolateral spine fusion modelFusion massRabbit modelSubcutaneous mini-osmotic pumpsPosterolateral lumbar fusion modelMini-osmotic pumpsNew Zealand white rabbitsNew Zealand white rabbit modelZealand white rabbitsPosterolateral spine fusionSpine fusion modelPosterolateral intertransverse process fusionWhite rabbit modelPresence of nicotineIntertransverse process fusionBone graft alternativesBony fusionBACKGROUND DATASpine fusionFlexibility Analysis of Posterolateral Fusions in a New Zealand White Rabbit Model
Erulkar J, Grauer J, Patel T, Panjabi M. Flexibility Analysis of Posterolateral Fusions in a New Zealand White Rabbit Model. Spine 2001, 26: 1125-1130. PMID: 11413423, DOI: 10.1097/00007632-200105150-00006.Peer-Reviewed Original ResearchConceptsPosterolateral fusionRabbit modelAutogenous iliac crest bone graftIliac crest bone graftTime pointsNew Zealand white rabbitsPosterolateral lumbar fusionAdult New Zealand white rabbitsCrest bone graftNew Zealand white rabbit modelZealand white rabbitsHuman cadaveric studyPosterolateral spinal fusionWhite rabbit modelVivo rabbit modelIntertransverse process fusionLumbar fusionClinical studiesBACKGROUND DATASpinal fusionAnimal studiesCadaveric studyBone graftWhite rabbitsManual palpation