2010
Augmented demineralized bone matrix: a potential alternative for posterolateral lumbar spinal fusion.
Biswas D, Bible JE, Whang PH, Miller CP, Jaw R, Miller S, Grauer JN. Augmented demineralized bone matrix: a potential alternative for posterolateral lumbar spinal fusion. The American Journal Of Orthopedics 2010, 39: 531-8. PMID: 21623419.Peer-Reviewed Original ResearchConceptsFusion rateGraft alternativesPosterolateral lumbar spinal fusionLumbar spinal fusionRhBMP-2Spine fusion modelDose-response curveEctopic bone formation modelBone graft alternativesStudy ratsLumbar fusionRat modelSpinal fusionSpine fusionB graftsRecombinant human bone morphogenetic protein-2Manual palpationHuman bone morphogenetic protein-2Bone matrix productsSignificant differencesProtein 2DBM carrierBone matrixAutograftBone morphogenetic protein-2
2006
Bone Morphogenetic Protein for Pseudarthrosis Repair in Revision Cervical Spine Surgery
White A, Lee R, Grauer J. Bone Morphogenetic Protein for Pseudarthrosis Repair in Revision Cervical Spine Surgery. Seminars In Spine Surgery 2006, 18: 207-210. DOI: 10.1053/j.semss.2006.09.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCervical spine surgeryRevision cervical spine surgeryAnterior cervical spine surgeryRecombinant human bone morphogenetic proteinSpine surgeryProspective clinical studyOff-label useBone morphogenetic proteinCervical surgeryBone graft alternativesPseudarthrosis repairClinical studiesSurgical techniqueAppropriate doseAnimal modelsSurgeryGraft alternativesHuman bone morphogenetic proteinMorphogenetic proteinsPotent osteoinductive factorsRecent reportsOsteoinductive factorsComplicationsPseudarthrosesDose
2004
Comparison of Posterolateral Lumbar Fusion Rates of Grafton Putty and OP-1 Putty in an Athymic Rat Model
Bomback DA, Grauer JN, Lugo R, Troiano N, Patel TCh, Friedlaender GE. Comparison of Posterolateral Lumbar Fusion Rates of Grafton Putty and OP-1 Putty in an Athymic Rat Model. Spine 2004, 29: 1612-1617. PMID: 15284503, DOI: 10.1097/01.brs.0000132512.53305.a1.Peer-Reviewed Original ResearchConceptsOP-1 PuttyFusion rateSpine fusion modelManual palpationOP-1Posterolateral lumbar spine fusionLumbar spine fusionSimilar fusion ratesAthymic nude ratsSpine fusion ratesLumbar fusion ratesAthymic rat modelIntertransverse process fusionBone graft alternativesInflammatory responseRat modelBACKGROUND DATASpine fusionStudy groupNude ratsOsteogenic protein-1Athymic ratsFusion massOsteoinductive productsGraft alternatives