2009
Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP
Yu J, Sheung N, Soliman EM, Spirli C, Dranoff JA. Transcriptional regulation of IL-6 in bile duct epithelia by extracellular ATP. AJP Gastrointestinal And Liver Physiology 2009, 296: g563-g571. PMID: 19136380, PMCID: PMC2660176, DOI: 10.1152/ajpgi.90502.2008.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAntibodiesBile DuctsCalciumCalcium SignalingCell Line, TransformedCell Line, TumorCyclic AMPEpithelial CellsExtracellular SpaceFibroblastsHumansImmunoblottingInterleukin-6MaleMutagenesis, Site-DirectedPromoter Regions, GeneticRatsRats, Sprague-DawleyReceptors, Purinergic P2Response ElementsRNA, MessengerSignal TransductionTranscriptional ActivationConceptsBile duct epitheliumIL-6IL-6 transcriptionDuct epitheliumLiver injuryCAMP response elementP2Y11 receptorInflammatory cytokines IL-6Extracellular ATPIL-6 upregulationUse of agonistsRat bile duct epitheliaCytokines IL-6IL-6 releaseIL-6 promoter activityIL-6 mRNAExtracellular ATP actsCalcium agonistP2Y receptorsPharmacological profileHepatic responseCalcium-dependent fashionExtracellular nucleotidesCytosolic calciumPurinergic signals
2008
Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition
Sohail MA, Hashmi AZ, Hakim W, Watanabe A, Zipprich A, Groszmann RJ, Dranoff JA, Torok NJ, Mehal WZ. Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibition. Hepatology 2008, 49: 185-194. PMID: 18844235, PMCID: PMC3129263, DOI: 10.1002/hep.22589.Peer-Reviewed Original Research
1999
Short‐term regulation of bile acid uptake by microfilament‐dependent translocation of rat ntcp to the plasma membrane
Dranoff J, McClure M, Burgstahler A, Denson L, Crawford A, Crawford J, Karpen S, Nathanson M. Short‐term regulation of bile acid uptake by microfilament‐dependent translocation of rat ntcp to the plasma membrane. Hepatology 1999, 30: 223-229. PMID: 10385660, DOI: 10.1002/hep.510300136.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonAnimalsBase SequenceBile Acids and SaltsBiological TransportCarcinoma, HepatocellularCarrier ProteinsCell MembraneCyclic AMPCytochalasin DGreen Fluorescent ProteinsHumansKineticsLiver NeoplasmsLuminescent ProteinsMembrane Transport ProteinsModels, MolecularMolecular Sequence DataOpen Reading FramesOrganic Anion Transporters, Sodium-DependentProtein Structure, SecondaryRatsRecombinant Fusion ProteinsSymportersTaurocholic AcidTransfectionTritiumTumor Cells, CulturedConceptsPlasma membraneGreen fluorescence proteinGFP fluorescenceNTCP-GFPPlasma membrane fluorescenceMembrane fluorescenceRat NtcpInhibitor of microfilamentsSecond messenger adenosinePrimary transporterFluorescence proteinNocodazole removalCytochalasin DTransporter activityShort-term regulationAcid uptakeConfocal video microscopyMicrotubule inhibitorsHepG2 cellsTaurocholate cotransportMembraneProteinMicrofilamentsCellsVideo microscopyRegulation of bile acid transport: Beyond molecular cloning
Dranoff J, Nathanson M. Regulation of bile acid transport: Beyond molecular cloning. Hepatology 1999, 29: 1912-1913. PMID: 10347140, DOI: 10.1002/hep.510290643.Peer-Reviewed Original Research