1999
Short‐term regulation of bile acid uptake by microfilament‐dependent translocation of rat ntcp to the plasma membrane
Dranoff J, McClure M, Burgstahler A, Denson L, Crawford A, Crawford J, Karpen S, Nathanson M. Short‐term regulation of bile acid uptake by microfilament‐dependent translocation of rat ntcp to the plasma membrane. Hepatology 1999, 30: 223-229. PMID: 10385660, DOI: 10.1002/hep.510300136.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonAnimalsBase SequenceBile Acids and SaltsBiological TransportCarcinoma, HepatocellularCarrier ProteinsCell MembraneCyclic AMPCytochalasin DGreen Fluorescent ProteinsHumansKineticsLiver NeoplasmsLuminescent ProteinsMembrane Transport ProteinsModels, MolecularMolecular Sequence DataOpen Reading FramesOrganic Anion Transporters, Sodium-DependentProtein Structure, SecondaryRatsRecombinant Fusion ProteinsSymportersTaurocholic AcidTransfectionTritiumTumor Cells, CulturedConceptsPlasma membraneGreen fluorescence proteinGFP fluorescenceNTCP-GFPPlasma membrane fluorescenceMembrane fluorescenceRat NtcpInhibitor of microfilamentsSecond messenger adenosinePrimary transporterFluorescence proteinNocodazole removalCytochalasin DTransporter activityShort-term regulationAcid uptakeConfocal video microscopyMicrotubule inhibitorsHepG2 cellsTaurocholate cotransportMembraneProteinMicrofilamentsCellsVideo microscopy
1998
Stimulation of bile duct epithelial secretion by glybenclamide in normal and cholestatic rat liver.
Nathanson MH, Burgstahler AD, Mennone A, Dranoff JA, Rios-Velez L. Stimulation of bile duct epithelial secretion by glybenclamide in normal and cholestatic rat liver. Journal Of Clinical Investigation 1998, 101: 2665-2676. PMID: 9637700, PMCID: PMC508857, DOI: 10.1172/jci2835.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBileBile DuctsBiological TransportCholestasisEpithelial CellsGlyburideHypoglycemic AgentsLiverMaleRatsRats, Sprague-DawleyConceptsBile duct epitheliumBicarbonate excretionBile flowDuct epitheliumImportant new therapeutic targetStimulatory effectBile duct segmentsBile duct cellsRat liverNew therapeutic targetsCardinal complicationLiver diseaseCholestatic disordersSecond messenger systemsCholestatic rat liverTherapeutic targetMeasurement of cAMPGlybenclamideEpithelial secretionDuct cellsDuct segmentsHepatocyte coupletsLiverExcretionEpithelium