2007
Succinate is a paracrine signal for liver damage
Correa PR, Kruglov EA, Thompson M, Leite MF, Dranoff JA, Nathanson MH. Succinate is a paracrine signal for liver damage. Journal Of Hepatology 2007, 47: 262-269. PMID: 17451837, PMCID: PMC1986575, DOI: 10.1016/j.jhep.2007.03.016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFluorescent Antibody TechniqueIn Vitro TechniquesInfusions, IntravenousIschemiaLiverLiver DiseasesMaleParacrine CommunicationPerfusionPortal VeinPressureRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledReverse Transcriptase Polymerase Chain ReactionSignal TransductionSuccinic AcidTissue DistributionConceptsHepatic stellate cellsSuccinate receptorParacrine signalsStellate cell activationStellate cellsCell expression systemTime-lapse imagingRelease of succinateCell activationCytosolic Ca2Effect of succinatePrimary hepatic stellate cellsHepatic cell typesExpression systemQuiescent hepatic stellate cellsConfocal immunofluorescencePhysiological roleIschemic hepatocytesCell typesBiochemical assaysSingle cellsLiver damageBACKGROUND/Western blotCAMP production
2005
The Anti-apoptotic Protein Mcl-1 Inhibits Mitochondrial Ca2+ Signals*
Minagawa N, Kruglov EA, Dranoff JA, Robert ME, Gores GJ, Nathanson MH. The Anti-apoptotic Protein Mcl-1 Inhibits Mitochondrial Ca2+ Signals*. Journal Of Biological Chemistry 2005, 280: 33637-33644. PMID: 16027162, DOI: 10.1074/jbc.m503210200.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAniline CompoundsAntibodies, MonoclonalApoptosisBile Duct NeoplasmsCalcium SignalingCarbocyaninesCell LineCell Line, TumorCell NucleusFluorescent Antibody Technique, IndirectFluorescent DyesHeterocyclic Compounds, 3-RingHumansHydrazinesImmunohistochemistryMicroscopy, ConfocalMitochondriaModels, BiologicalMyeloid Cell Leukemia Sequence 1 ProteinNeoplasm ProteinsProto-Oncogene Proteins c-bcl-2Signal TransductionTissue DistributionXanthenesConceptsAnti-apoptotic proteinsMcl-1Mitochondrial Ca2Mcl-1 expressionApoptotic stimuliEndoplasmic reticulum Ca2Trisphosphate receptorCell growthNovel mechanismApoptosisMechanism of actionProteinExpressionDevelopment of neoplasiaCa2Reticulum Ca2CellsMitochondriaInositolRegulationPathwayMechanismSignalsReceptorsRegeneration