Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis.
Dranoff J, Kruglov E, Toure J, Braun N, Zimmermann H, Jain D, Knowles A, Sévigny J. Ectonucleotidase NTPDase2 Is Selectively Down-Regulated in Biliary Cirrhosis. Journal Of Investigative Medicine 2004, 52: 475. DOI: 10.1097/00042871-200411000-00042.Peer-Reviewed Original ResearchBile duct ligationNTPDase2 expressionPrimary biliary cirrhosisBiliary cirrhosisPortal fibroblastsReal-time polymerase chain reactionCCl4 administrationPolymerase chain reactionBiopsy specimensPortal areasExperimental ratsFibrous bandsNormal liverConfocal immunofluorescenceExpression of NTPDase2Fibrogenic liver cellsHepatitis C. ConclusionsHepatitis C cirrhosisLiver biopsy specimensFibrotic liver diseaseChain reactionHuman liver biopsy specimensHepatic stellate cellsNew therapeutic approachesSmooth muscle actin