2020
Purinergic Regulation of Bile Ductular Secretion
Dranoff J. Purinergic Regulation of Bile Ductular Secretion. 2020, 96-104. DOI: 10.1201/9780367813888-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsP2Y receptorsPurinergic receptorsIntestinal epitheliumExtracellular nucleotidesP2Y receptor subtypesP2 receptorsReceptor subtypesRespiratory epitheliumP1 receptorsMucin secretionNucleotide receptorsPurinergic agonistsPlatelet aggregationPurinergic regulationChloride secretionDistinct receptorsDuctular secretionNucleoside receptorsEpithelial secretionEpitheliumReceptorsSalivary glandsSecretionSecretory epitheliumRenal epithelium
1998
Stimulation of bile duct epithelial secretion by glybenclamide in normal and cholestatic rat liver.
Nathanson MH, Burgstahler AD, Mennone A, Dranoff JA, Rios-Velez L. Stimulation of bile duct epithelial secretion by glybenclamide in normal and cholestatic rat liver. Journal Of Clinical Investigation 1998, 101: 2665-2676. PMID: 9637700, PMCID: PMC508857, DOI: 10.1172/jci2835.Peer-Reviewed Original ResearchConceptsBile duct epitheliumBicarbonate excretionBile flowDuct epitheliumImportant new therapeutic targetStimulatory effectBile duct segmentsBile duct cellsRat liverNew therapeutic targetsCardinal complicationLiver diseaseCholestatic disordersSecond messenger systemsCholestatic rat liverTherapeutic targetMeasurement of cAMPGlybenclamideEpithelial secretionDuct cellsDuct segmentsHepatocyte coupletsLiverExcretionEpithelium