1988
Proteolytic processing of human brain alpha spectrin (fodrin): identification of a hypersensitive site
Harris A, Morrow J. Proteolytic processing of human brain alpha spectrin (fodrin): identification of a hypersensitive site. Journal Of Neuroscience 1988, 8: 2640-2651. PMID: 3074159, PMCID: PMC6569499, DOI: 10.1523/jneurosci.08-07-02640.1988.Peer-Reviewed Original ResearchConceptsLong-term potentiationBrain spectrinCalcium-dependent mechanismCalcium-dependent neutral proteaseCalcium-dependent proteaseCentral molecular mechanismsSite of actionReceptor functionPostsynaptic membraneCalcium-dependent mannerFurther investigationMolecular mechanismsGel overlay techniqueAlpha subunitNeutral proteaseNonerythroid spectrinImportant moleculesProteolytic processingCleavage fragmentsPotentiationProtease
1987
Spectrin Is Associated With Membrane-Bound Actin Filaments in Platelets and Is Hydrolyzed by the Ca2+-Dependent Protease During Platelet Activation
Fox J, Reynolds C, Morrow J, Phillips D. Spectrin Is Associated With Membrane-Bound Actin Filaments in Platelets and Is Hydrolyzed by the Ca2+-Dependent Protease During Platelet Activation. Blood 1987, 69: 537-545. DOI: 10.1182/blood.v69.2.537.537.Peer-Reviewed Original ResearchActin filamentsDependent proteasePlasma membraneRBC spectrinSubmembranous actin filamentsActin-binding proteinsBeta chainMembrane-bound filamentsActin filament networkTriton XImmunoprecipitation experimentsMinor polypeptidesFilament networkSpectrinGlycoprotein IbBrain spectrinDifferential centrifugationPresence of Ca2ProteaseLysatesPolyacrylamide gelsUnstimulated plateletsPolypeptideUnidentified componentsN-ethylmaleimide