Transforming Growth Factor β Induces Caspase 3-independent Cleavage of αII-Spectrin (α-Fodrin) Coincident with Apoptosis*
Brown T, Patil S, Cianci C, Morrow J, Howe P. Transforming Growth Factor β Induces Caspase 3-independent Cleavage of αII-Spectrin (α-Fodrin) Coincident with Apoptosis*. Journal Of Biological Chemistry 1999, 274: 23256-23262. PMID: 10438500, DOI: 10.1074/jbc.274.33.23256.Peer-Reviewed Original ResearchConceptsAlphaII-spectrinBroad-spectrum caspase inhibitorDistinct apoptotic pathwaysImmature B cell linesOnset of apoptosisCaspase-3 activationInduction of apoptosisPotent growth inhibitorNovel caspaseCaspase inhibitorsWEHI-231Cytoskeletal actinApoptotic pathwayB cell linesNovel substrateCell deathGrowth factor betaFirst direct evidenceCaspase-3ApoptosisCell linesCaspasesGrowth inhibitorFactor betaFirst evidence