Spectrin Is Associated With Membrane-Bound Actin Filaments in Platelets and Is Hydrolyzed by the Ca2+-Dependent Protease During Platelet Activation
Fox J, Reynolds C, Morrow J, Phillips D. Spectrin Is Associated With Membrane-Bound Actin Filaments in Platelets and Is Hydrolyzed by the Ca2+-Dependent Protease During Platelet Activation. Blood 1987, 69: 537-545. DOI: 10.1182/blood.v69.2.537.537.Peer-Reviewed Original ResearchActin filamentsDependent proteasePlasma membraneRBC spectrinSubmembranous actin filamentsActin-binding proteinsBeta chainMembrane-bound filamentsActin filament networkTriton XImmunoprecipitation experimentsMinor polypeptidesFilament networkSpectrinGlycoprotein IbBrain spectrinDifferential centrifugationPresence of Ca2ProteaseLysatesPolyacrylamide gelsUnstimulated plateletsPolypeptideUnidentified componentsN-ethylmaleimide