2003
Identification of the primary caspase 3 cleavage site in alpha II-spectrin during apoptosis
Williams S, Smith A, Cianci C, Morrow J, Brown T. Identification of the primary caspase 3 cleavage site in alpha II-spectrin during apoptosis. Apoptosis 2003, 8: 353-361. PMID: 12815278, DOI: 10.1023/a:1024168901003.Peer-Reviewed Original ResearchConceptsCaspase-3 cleavage siteCleavage sitePrimary cleavage siteII-spectrinCytoskeletal integrityAlpha II spectrinMembrane stabilityCaspase-3Cleavage of alphaApoptotic cell deathCaspase-3 activationMature B cellsConsensus sitesDeletion analysisTranscriptional inhibitorMajor proteinsLikely altersApoptotic bodiesCell deathProteinStructural conformationActinomycin DSpectrinNew insightsApoptosis
1999
Transforming Growth Factor β Induces Caspase 3-independent Cleavage of αII-Spectrin (α-Fodrin) Coincident with Apoptosis*
Brown T, Patil S, Cianci C, Morrow J, Howe P. Transforming Growth Factor β Induces Caspase 3-independent Cleavage of αII-Spectrin (α-Fodrin) Coincident with Apoptosis*. Journal Of Biological Chemistry 1999, 274: 23256-23262. PMID: 10438500, DOI: 10.1074/jbc.274.33.23256.Peer-Reviewed Original ResearchConceptsAlphaII-spectrinBroad-spectrum caspase inhibitorDistinct apoptotic pathwaysImmature B cell linesOnset of apoptosisCaspase-3 activationInduction of apoptosisPotent growth inhibitorNovel caspaseCaspase inhibitorsWEHI-231Cytoskeletal actinApoptotic pathwayB cell linesNovel substrateCell deathGrowth factor betaFirst direct evidenceCaspase-3ApoptosisCell linesCaspasesGrowth inhibitorFactor betaFirst evidence