2020
“Small” Intestinal Immunopathology Plays a “Big” Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-γ, IL-17A, and a Janus Kinase Inhibitor
Kale SD, Mehrkens BN, Stegman MM, Kastelberg B, Carnes H, McNeill RJ, Rizzo A, Karyala SV, Coutermarsh-Ott S, Fretz JA, Sun Y, Koff JL, Rajagopalan G. “Small” Intestinal Immunopathology Plays a “Big” Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-γ, IL-17A, and a Janus Kinase Inhibitor. Frontiers In Immunology 2020, 11: 1311. PMID: 32676080, PMCID: PMC7333770, DOI: 10.3389/fimmu.2020.01311.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCoronavirus InfectionsCOVID-19Cytokine Release SyndromeCytokinesHLA-DR3 AntigenInterferon-gammaInterleukin-17Intestine, SmallJanus Kinase InhibitorsLymphocyte ActivationMiceMice, KnockoutNitrilesPandemicsPneumonia, ViralPyrazolesPyrimidinesT-Lymphocytes, Helper-InducerConceptsSmall bowel pathologyMultiple organ dysfunctionIL-17A deficiencySmall intestinal immunopathologyCytokine release syndromeToxic shock syndromeBowel pathologyIntestinal immunopathologyRelease syndromeChimeric antigen receptor T-cell therapySevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Immune check point inhibitorsHLA-DR3 transgenic miceRespiratory syndrome coronavirus 2HLA-DR3 miceIFN-γ deficiencyCheck point inhibitorsSyndrome coronavirus 2T-cell therapyJAK 1/2 inhibitorJanus kinase inhibitorSmall intestinal tissueCoronavirus disease 2019T cell activation
2008
Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium
Koff JL, Shao MX, Ueki IF, Nadel JA. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2008, 294: l1068-l1075. PMID: 18375743, DOI: 10.1152/ajplung.00025.2008.Peer-Reviewed Original ResearchMeSH KeywordsADAM ProteinsADAM17 ProteinBronchiCells, CulturedDual OxidasesErbB ReceptorsHumansImmunity, InnateInterleukin-8NADPH OxidasesReactive Oxygen SpeciesRespiratory MucosaRNA, Small InterferingSignal TransductionToll-Like ReceptorsTransforming Growth Factor alphaVascular Endothelial Growth Factor AConceptsToll-like receptorsTNF-alpha converting enzymeInnate immune responseMultiple Toll-like receptorsIL-8Immune responseTGF-alphaVEGF productionTLR ligandsAirway epitheliumEpithelial cellsCertain innate immune responsesEGF receptorMultiple TLR ligandsAirway epithelial surfaceAirway epithelial cell lineNormal human bronchial epithelial cellsEpithelial cell productionAirway epithelial cellsHuman bronchial epithelial cellsNADPH oxidase inhibitorBronchial epithelial cellsEpithelial cell lineReactive oxygen species (ROS) scavengerEpithelial production