2023
Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia
Castaneda D, Jangra S, Yurieva M, Martinek J, Callender M, Coxe M, Choi A, Diego J, Lin J, Wu T, Marches F, Chaussabel D, Yu P, Salner A, Aucello G, Koff J, Hudson B, Church S, Gorman K, Anguiano E, García-Sastre A, Williams A, Schotsaert M, Palucka K. Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia. IScience 2023, 26: 107374. PMID: 37520727, PMCID: PMC10374611, DOI: 10.1016/j.isci.2023.107374.Peer-Reviewed Original ResearchHuman air-liquid interface culturesAir-liquid interface culturesNucleoprotein expressionAirway epithelial cellsSARS-CoV-2 variant infectionResponse to virusesUnmet medical needCSF3 expressionInterface culturesImmune responseEpithelial cellsDay 4Severe diseaseVariant infectionBasal cellsTranscriptional signatureSARS-CoV-2InfectionApical cellsEarly responseMedical needSARS-CoV-2 virusEpitheliaVirusPost-infection
2013
Respiratory virus–induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium
Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. Respiratory virus–induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium. Journal Of Experimental Medicine 2013, 210: 1929-1936. PMID: 23999497, PMCID: PMC3782052, DOI: 10.1084/jem.20121401.Peer-Reviewed Original ResearchConceptsEpithelial epidermal growth factor receptorViral infectionHost responseInnate antiviral host responsesEGFR activationIFN-λ productionIFN-λ signalingAntiviral immune responseImportance of IFNType III IFNsAntiviral defenseAntiviral host responseEpidermal growth factor receptorGrowth factor receptorSignificant IFNTyrosine kinase receptorsInterferon λNovel therapiesAirway epitheliumIFN regulatory factor-1Immune responseFuture therapiesViral pathogenesisAntiviral responseIFN
2008
Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium
Koff JL, Shao MX, Ueki IF, Nadel JA. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2008, 294: l1068-l1075. PMID: 18375743, DOI: 10.1152/ajplung.00025.2008.Peer-Reviewed Original ResearchMeSH KeywordsADAM ProteinsADAM17 ProteinBronchiCells, CulturedDual OxidasesErbB ReceptorsHumansImmunity, InnateInterleukin-8NADPH OxidasesReactive Oxygen SpeciesRespiratory MucosaRNA, Small InterferingSignal TransductionToll-Like ReceptorsTransforming Growth Factor alphaVascular Endothelial Growth Factor AConceptsToll-like receptorsTNF-alpha converting enzymeInnate immune responseMultiple Toll-like receptorsIL-8Immune responseTGF-alphaVEGF productionTLR ligandsAirway epitheliumEpithelial cellsCertain innate immune responsesEGF receptorMultiple TLR ligandsAirway epithelial surfaceAirway epithelial cell lineNormal human bronchial epithelial cellsEpithelial cell productionAirway epithelial cellsHuman bronchial epithelial cellsNADPH oxidase inhibitorBronchial epithelial cellsEpithelial cell lineReactive oxygen species (ROS) scavengerEpithelial production