2024
Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University
Würstle S, Lee A, Kortright K, Winzig F, An W, Stanley G, Rajagopalan G, Harris Z, Sun Y, Hu B, Blazanin M, Hajfathalian M, Bollyky P, Turner P, Koff J, Chan B. Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University. Scientific Reports 2024, 14: 2657. PMID: 38302552, PMCID: PMC10834462, DOI: 10.1038/s41598-024-52192-3.Peer-Reviewed Original ResearchConceptsEvolutionary selection pressurePhage characterizationPhage therapyPersistent bacterial infectionsBacteriophage therapyPhageSelection pressurePseudomonas aeruginosaInvestigational new drug applicationBacterial infectionsNew Drug ApplicationTherapyDrug applicationClinical applicationAutographiviridaeBacteriaPotential strategy
2021
Bacteriophage therapy for infections in CF
Chan BK, Stanley G, Modak M, Koff JL, Turner PE. Bacteriophage therapy for infections in CF. Pediatric Pulmonology 2021, 56: s4-s9. PMID: 33434411, DOI: 10.1002/ppul.25190.Peer-Reviewed Original ResearchConceptsCystic fibrosisPhage therapyBacteriophage therapyBacterial pathogensAntibiotic-resistant bacterial infectionsPulmonary complicationsClinical benefitCase reportLung infectionClinical trialsDisease progressionTarget bacterial pathogensTherapyBacterial infectionsNovel management strategiesPatient treatmentPatient dataInfectionStaphylococcus aureusTrialsPseudomonas aeruginosaPotential usefulnessPathogensLytic phagesComplications
2019
Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria
Kortright KE, Chan BK, Koff JL, Turner PE. Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria. Cell Host & Microbe 2019, 25: 219-232. PMID: 30763536, DOI: 10.1016/j.chom.2019.01.014.Peer-Reviewed Original ResearchConceptsPhage therapyRecent case reportsAntibiotic-resistant bacteriaResistant bacterial infectionsCase reportChemical antibioticsClinical trialsClinical utilityIntractable infectionsAnimal modelsTherapyBacterial infectionsWestern medicineCombat Antibiotic-Resistant BacteriaPhage therapy researchInfectionAntibioticsTherapy researchPhage resistanceClinicTrials
2007
Regulation of interleukin-8 via an airway epithelial signaling cascade
Nakanaga T, Nadel JA, Ueki IF, Koff JL, Shao MX. Regulation of interleukin-8 via an airway epithelial signaling cascade. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2007, 292: l1289-l1296. PMID: 17220369, DOI: 10.1152/ajplung.00356.2006.Peer-Reviewed Original ResearchConceptsIL-8 productionIL-8 expressionHuman airway epithelial NCI-H292 cellsEGF receptorNeutrophil chemoattractant interleukinEpithelial cellsNCI-H292 cellsAirway epithelial cellsModel inflammatory stimulusNegative bacterial lipopolysaccharideDual oxidase 1MAP kinases ERK1/2IL-8Tumor necrosisInterleukin-8Immune organsInflammatory stimuliMucin productionHuman airwaysAirwayEpithelial defenseTACE activationBacterial infectionsHost defenseConverting enzyme