2007
Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus
Andrioli A, Alonso-Nanclares L, Arellano J, DeFelipe J. Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus. Neuroscience 2007, 149: 131-143. PMID: 17850980, DOI: 10.1016/j.neuroscience.2007.07.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCell CountEpilepsyFemaleHippocampusHumansMaleMiddle AgedParvalbuminsStereotaxic TechniquesConceptsNeuronal lossProtein parvalbuminIntractable temporal lobe epilepsyCalcium binding protein parvalbuminParvalbumin-immunoreactive cellsTotal neuronal lossHippocampal neuronal lossParvalbumin-immunoreactive neuronsPV-ir neuronsHuman epileptic hippocampusMesial temporal structuresTemporal lobe epilepsyBinding protein parvalbuminTotal neuronal densityQuantitative stereological methodsAutopsy hippocampiAxonal reorganizationPV-irHippocampal sclerosisEpileptic hippocampusLobe epilepsyNeuronal densityInhibitory circuitsEpileptogenic processGABAergic interneurons
2005
Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex
Benavides-Piccione R, Arellano J, DeFelipe J. Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex. Cerebral Cortex 2005, 15: 1584-1591. PMID: 15703259, DOI: 10.1093/cercor/bhi036.Peer-Reviewed Original ResearchConceptsHuman temporal cortexPyramidal cellsPyramidal neuronsCatecholaminergic innervationCatecholaminergic afferentsCatecholaminergic fibersTyrosine hydroxylaseTemporal cortexHuman neocortexBasal dendritic regionsBasal dendritic arborsHuman cortical organizationEnzyme tyrosine hydroxylaseHuman cortical tissueDendritic arborsExcitatory inputsCortical functionLayers IIHigher cognitive functionsLayers IIIaCognitive functionDendritic compartmentsCortical tissueCortical organizationLucifer Yellow
2004
CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin‐1 E280A Mutation Is Related to Epilepsy
Velez‐Pardo C, Arellano J, Cardona‐Gomez P, Del Rio M, Lopera F, De Felipe J. CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin‐1 E280A Mutation Is Related to Epilepsy. Epilepsia 2004, 45: 751-756. PMID: 15230697, DOI: 10.1111/j.0013-9580.2004.55403.x.Peer-Reviewed Original ResearchConceptsHippocampal neuronal lossNeuronal lossCA1 fieldAlzheimer's diseaseFAD patientsEpileptic seizuresPresenilin-1 E280A mutationMesial temporal lobe structuresAppearance of epilepsyCA1 hippocampal regionNeuronal cell lossSubpopulation of patientsFamilial AD patientsTemporal lobe structuresPresenilin 1 mutationNeuronal depopulationHippocampal sclerosisAD pathologyAD patientsNeurofibrillary tanglesEpilepsy patientsHippocampal regionHippocampal formationPatientsCoronal sections
2002
Microstructure of the neocortex: Comparative aspects
DeFelipe J, Alonso-Nanclares L, Arellano J. Microstructure of the neocortex: Comparative aspects. Brain Cell Biology 2002, 31: 299-316. PMID: 12815249, DOI: 10.1023/a:1024130211265.Peer-Reviewed Original ResearchConceptsDifferent cortical areasCortical areasExtrinsic afferent systemsNeocortex of humansInhibitory GABAergic interneuronsDensity of excitatoryNumber of synapsesSpecific cortical circuitsDistinct cortical areasSpiny cellsInhibitory circuitsGABAergic interneuronsInhibitory synapsesNeocortical neuronsNeuronal elementsPyramidal cellsAfferent systemsCortical circuitsNeocortical circuitsCortical tissueNumber of neuronsNeocortexNeuronsExcitatoryBasic microcircuit