2006
Non-synaptic dendritic spines in neocortex
Arellano J, Espinosa A, Fairén A, Yuste R, DeFelipe J. Non-synaptic dendritic spines in neocortex. Neuroscience 2006, 145: 464-469. PMID: 17240073, DOI: 10.1016/j.neuroscience.2006.12.015.Peer-Reviewed Original Research
2005
Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex
Benavides-Piccione R, Arellano J, DeFelipe J. Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex. Cerebral Cortex 2005, 15: 1584-1591. PMID: 15703259, DOI: 10.1093/cercor/bhi036.Peer-Reviewed Original ResearchConceptsHuman temporal cortexPyramidal cellsPyramidal neuronsCatecholaminergic innervationCatecholaminergic afferentsCatecholaminergic fibersTyrosine hydroxylaseTemporal cortexHuman neocortexBasal dendritic regionsBasal dendritic arborsHuman cortical organizationEnzyme tyrosine hydroxylaseHuman cortical tissueDendritic arborsExcitatory inputsCortical functionLayers IIHigher cognitive functionsLayers IIIaCognitive functionDendritic compartmentsCortical tissueCortical organizationLucifer Yellow
2004
CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin‐1 E280A Mutation Is Related to Epilepsy
Velez‐Pardo C, Arellano J, Cardona‐Gomez P, Del Rio M, Lopera F, De Felipe J. CA1 Hippocampal Neuronal Loss in Familial Alzheimer's Disease Presenilin‐1 E280A Mutation Is Related to Epilepsy. Epilepsia 2004, 45: 751-756. PMID: 15230697, DOI: 10.1111/j.0013-9580.2004.55403.x.Peer-Reviewed Original ResearchConceptsHippocampal neuronal lossNeuronal lossCA1 fieldAlzheimer's diseaseFAD patientsEpileptic seizuresPresenilin-1 E280A mutationMesial temporal lobe structuresAppearance of epilepsyCA1 hippocampal regionNeuronal cell lossSubpopulation of patientsFamilial AD patientsTemporal lobe structuresPresenilin 1 mutationNeuronal depopulationHippocampal sclerosisAD pathologyAD patientsNeurofibrillary tanglesEpilepsy patientsHippocampal regionHippocampal formationPatientsCoronal sections
2001
Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex
DeFelipe J, Arellano J, Gómez A, Azmitia E, Muñoz A. Pyramidal cell axons show a local specialization for GABA and 5‐HT inputs in monkey and human cerebral cortex. The Journal Of Comparative Neurology 2001, 433: 148-155. PMID: 11283956, DOI: 10.1002/cne.1132.Peer-Reviewed Original ResearchConceptsChandelier cell axon terminalsGamma-aminobutyric acidPyramidal cell axonsCerebral cortexPyramidal cellsAxon terminalsCell axonsHuman cerebral cortexDouble-labeling experimentsPowerful inhibitory mechanismChandelier cellsMonkey neocortexGABAergic interneuronsImmunoreactive fibersSerotonin receptorsSerotonin afferentsAxonal specializationsParacrine mannerLayers IISynaptic connectionsImmunocytochemical methodsProximal portionInhibitory mechanismClose appositionConfocal laser microscopy
1999
Variation in the spatial relationship between parvalbumin immunoreactive interneurones and pyramidal neurones in rat somatosensory cortex
Elston G, DeFelipe J, Arellano J, del Carmen Gonzilez-Albo M, Rosa M. Variation in the spatial relationship between parvalbumin immunoreactive interneurones and pyramidal neurones in rat somatosensory cortex. Neuroreport 1999, 10: 2975-2979. PMID: 10549808, DOI: 10.1097/00001756-199909290-00019.Peer-Reviewed Original ResearchConceptsPyramidal neuronesLayer VLucifer YellowSomatosensory cortexLayer IIICell bodiesRat primary somatosensory cortexTangential cortical slicesPrimary somatosensory cortexImmunoreactive cell bodiesBasal dendritic fieldsRat somatosensory cortexCombination of antibodiesReceptive field propertiesDendritic territoriesCortical slicesInhibitory modulationDendritic fieldsCortical neuronesIntracellular injectionNeuronesCortexConfocal microscopyFunctional implicationsSlices