2023
Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques
Bathla S, Datta D, Liang F, Barthelemy N, Wiseman R, Slusher B, Asher J, Zeiss C, Ekanayake‐Alper D, Holden D, Terwilliger G, Duque A, Arellano J, van Dyck C, Bateman R, Xie Z, Nairn A, Arnsten A. Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2023, 9: e12431. PMID: 37915375, PMCID: PMC10617575, DOI: 10.1002/trc2.12431.Peer-Reviewed Original ResearchSporadic Alzheimer's diseaseEntorhinal cortexGCPII inhibitionDorsolateral prefrontal cortexChronic inhibitionTau pathologyTau hyperphosphorylationAged macaquesType 3 metabotropic glutamate receptorAlzheimer's diseasePrefrontal cortexRhesus macaquesVehicle-treated monkeysAged rhesus macaquesMetabotropic glutamate receptorsApparent side effectsAmyloid beta 1Regulation of calciumGCPII inhibitorsKey etiological factorGCPII activityPrimate dlPFCNeuronal damageCSF analysisCalcium dysregulationLocalization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease
Datta D, Perone I, Morozov Y, Arellano J, Duque A, Rakic P, van Dyck C, Arnsten A. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer’s disease. Cerebral Cortex 2023, 33: 11501-11516. PMID: 37874022, PMCID: PMC10724870, DOI: 10.1093/cercor/bhad382.Peer-Reviewed Original ResearchConceptsHCN1 channelsTau pathologyGlutamate synapsesEntorhinal cortexCalcium actionInternal calcium releaseEntorhinal cortex stellate cellsDorsolateral prefrontal cortexSusceptible neuronsInitial pathologySelective vulnerabilityEtiological factorsTau phosphorylationStellate cellsAlzheimer's diseaseSpecific neuronsCalcium releasePrefrontal cortexCortexSynapse strengthPathologyCalcium signalingCalbindinDiseaseNeurons
2002
PSA-NCAM Immunoreactivity in Chandelier Cell Axon Terminals of the Human Temporal Cortex
Arellano J, DeFelipe J, Muñoz A. PSA-NCAM Immunoreactivity in Chandelier Cell Axon Terminals of the Human Temporal Cortex. Cerebral Cortex 2002, 12: 617-624. PMID: 12003861, DOI: 10.1093/cercor/12.6.617.Peer-Reviewed Original ResearchConceptsChandelier cell axon terminalsPSA-NCAMLayers IIAxon terminalsPlastic changesAdult central nervous systemPSA-NCAM immunoreactivityDouble immunocytochemical stainingHuman temporal cortexHuman entorhinal cortexCentral nervous systemPV-immunoreactiveTemporal neocortexSerotonin receptorsEntorhinal cortexTemporal cortexNervous systemAxonal processesGABA transporterImmunocytochemical stainingGAT-1ParvalbuminNeocortexCortexPresent study
2001
Neuropathological Findings in a Patient with Epilepsy and the Parry–Romberg Syndrome
DeFelipe J, Segura T, Arellano J, Merchán A, DeFelipe‐Oroquieta J, Martín P, Maestú F, Cajal S, Sánchez A, Sola R. Neuropathological Findings in a Patient with Epilepsy and the Parry–Romberg Syndrome. Epilepsia 2001, 42: 1198-1203. PMID: 11580770, DOI: 10.1046/j.1528-1157.2001.45800.x.Peer-Reviewed Original ResearchConceptsParry-Romberg syndromeSeizure activityDentate gyrusIntractable temporal lobe epilepsyComplete seizure reliefPolymorph cell layerTemporal lobe epilepsyCause of epilepsyDentate gyrus circuitryNumber of synapsesStandard histopathologic methodsGamma-aminobutyric acidInhibitory basket cellsCell-sparse regionNeuropathologic findingsNeuropathological findingsSeizure reliefAxosomatic synapsesLobe epilepsySurgical interventionElectron microscopic levelMesial structuresEctopic massBasket cellsEntorhinal cortex