2014
Role of PTHrP in Mammary Gland Development and Breast Cancer
Hiremath M, Wysolmerski J. Role of PTHrP in Mammary Gland Development and Breast Cancer. Clinical & Translational Metabolism 2014, 12: 178-189. DOI: 10.1007/s12018-014-9170-9.Peer-Reviewed Original ResearchRole of PTHrPBreast cancerMammary glandOsteolytic bone lesionsPrimary breast cancerBreast cancer metastasisNormal mammary glandMammary cell fateMammary gland developmentMaternal calciumBone lesionsPrimary tumorMineral metabolismEmbryonic mammary developmentBreast pathogenesisNeonatal bonePTHrPMammary developmentCancer metastasisGland developmentSupply of calciumCancerGlandProtein signalingBone
2013
Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development
Hiremath M, Wysolmerski J. Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development. Journal Of Mammary Gland Biology And Neoplasia 2013, 18: 171-177. PMID: 23640717, PMCID: PMC3696739, DOI: 10.1007/s10911-013-9283-7.BooksConceptsParathyroid hormoneBreast cancerMammary rudimentsMammary budLoss of PTHrPOverexpression of PTHrPRole of PTHrPEffects of PTHrPNovel breast cancer susceptibility lociEpithelial-stromal crosstalkEmbryonic mammary budBreast cancer susceptibility lociEmbryonic mammary developmentMammary gland morphogenesisNipple skinDay 15PTHrP’s rolePTHrPMammary developmentMammary epithelial identityMammary mesenchymeCancer susceptibility lociCancerCritical regulatorHormone
2011
Parathyroid Hormone-Related Protein Is Not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary Gland
Boras-Granic K, VanHouten J, Hiremath M, Wysolmerski J. Parathyroid Hormone-Related Protein Is Not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary Gland. PLOS ONE 2011, 6: e27278. PMID: 22087279, PMCID: PMC3210770, DOI: 10.1371/journal.pone.0027278.Peer-Reviewed Original ResearchConceptsMammary glandPTHrP expressionAlveolar developmentMyoepithelial cellsMaternal calcium homeostasisOverexpression of PTHrPRole of PTHrPExpression of PTHrPEmbryonic mammary budPTHrP deficiencyMouse mammary glandParathyroid hormoneTransgenic miceDuctal developmentCalcium homeostasisAlveolar cellsPTHrPPubertal developmentMMTV-CrePost-natal mammary glandMammary developmentMammary budPostnatal mammary glandCre transgenePTHrP gene
1998
THE PHYSIOLOGY OF PARATHYROID HORMONE-RELATED PROTEIN: An Emerging Role as a Developmental Factor
Wysolmerski JJ, Stewart AF. THE PHYSIOLOGY OF PARATHYROID HORMONE-RELATED PROTEIN: An Emerging Role as a Developmental Factor. Annual Review Of Physiology 1998, 60: 431-460. PMID: 9558472, DOI: 10.1146/annurev.physiol.60.1.431.BooksConceptsRole of PTHrPHormone-related proteinVascular smooth muscle toneParathyroid hormone-related proteinSmooth muscle tonePancreatic islet massMechanism of actionIntracrine regulatorHumoral hypercalcemiaMuscle tonePathogenic roleIslet massPTHrPDevelopmental factorsMammary glandEmerging RoleCalcium transferCell deathNormal developmentalAdult physiologySecretory formCell growthHypercalcemiaMalignancySyndrome