Featured Publications
Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47
MacMicking JD, Taylor GA, McKinney JD. Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47. Science 2003, 302: 654-659. PMID: 14576437, DOI: 10.1126/science.1088063.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedComputational BiologyDisease SusceptibilityFemaleGTP PhosphohydrolasesGTP-Binding ProteinsHydrogen-Ion ConcentrationImmunity, InnateInterferon-gammaMacrophage ActivationMacrophagesMacrophages, AlveolarMaleMiceMice, Inbred C57BLMutationMycobacterium tuberculosisNitric Oxide SynthaseNitric Oxide Synthase Type IIOligonucleotide Array Sequence AnalysisPhagosomesReverse Transcriptase Polymerase Chain ReactionSignal TransductionTuberculosisConceptsNitric oxide synthase 2LRG-47Principal effector mechanismDefective bacterial killingImmune controlEffector mechanismsMtb replicationImpaired maturationBacterial killingIntracellular pathogensMycobacterium tuberculosisHost macrophagesInfected host macrophagesSynthase 2TuberculosisIRG-47MtbIFNDiseaseMiceMacrophages
1999
Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase
Shiloh M, MacMicking J, Nicholson S, Brause J, Potter S, Marino M, Fang F, Dinauer M, Nathan C. Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase. Immunity 1999, 10: 29-38. PMID: 10023768, DOI: 10.1016/s1074-7613(00)80004-7.Peer-Reviewed Original ResearchMeSH KeywordsAbscessAnimalsBacterial InfectionsCrosses, GeneticEscherichia coliGenetic Predisposition to DiseaseListeria monocytogenesListeriosisMacrophages, PeritonealMembrane GlycoproteinsMiceMice, Inbred C57BLMice, Inbred StrainsMice, KnockoutNADPH Oxidase 2NADPH OxidasesNitric Oxide SynthaseNitric Oxide Synthase Type IIPhenotypeSalmonella Infections, AnimalSalmonella typhimuriumConceptsInducible nitric oxide synthaseNitric oxide synthaseOxide synthaseSpecific pathogen-free conditionsPathogen-free conditionsPhagocyte oxidaseMassive abscessReactive oxygen intermediatesSuch infectionsPhenotype of miceCommensal organismsNitrogen intermediatesMiceOxygen intermediatesNOS2MacrophagesS. typhimuriumVirulent ListeriaEnteric bacteria
1998
Identification of Nitric Oxide Synthase 2 as an Innate Resistance Locus against Ectromelia Virus Infection
Karupiah G, Chen J, Nathan C, Mahalingam S, MacMicking J. Identification of Nitric Oxide Synthase 2 as an Innate Resistance Locus against Ectromelia Virus Infection. Journal Of Virology 1998, 72: 7703-7706. PMID: 9696880, PMCID: PMC110049, DOI: 10.1128/jvi.72.9.7703-7706.1998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineChlorocebus aethiopsEctromelia virusFemaleGene DeletionImmunity, InnateMaleMiceMice, Inbred C57BLMice, KnockoutNitric Oxide SynthaseNitric Oxide Synthase Type IIConceptsNitric oxide synthase 2NOS2-/- miceEctromelia virusCytotoxic T lymphocyte activityEctromelia virus infectionGamma interferon secretionT lymphocyte activityAcute viral infectionSynthase 2Lymphocyte activityNK cellsInterferon secretionVirus infectionImmune responseMonogenic determinantsViral infectionHost survivalCausative agentInfectionMousepoxSecretion